{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:04:35Z","timestamp":1792512275989,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Inadequate antioxidant balance may play a role in the excessive tissue breakdown in periodontitis. Because aggressive periodontitis (AgP) not only differs from chronic periodontitis (CP) in terms of clinical manifestations, this study investigates whether the salivary levels of glutathione reductase (GR) may be linked with periodontal status.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Saliva samples from patients with CP (n = 121), patients with AgP (n = 18), and healthy controls (n = 69) were collected. Periodontal status was assessed by criteria based on probing depth, clinical attachment level, and extent and severity of periodontal breakdown. GR salivary levels were analyzed by spectrophotometry. The association among GR concentration and CP or AgP was analyzed individually and adjusted for confounding using multivariate binary logistic regression models.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> GR levels not only differed significantly between the two periodontitis groups, being significantly greater in patients with AgP, but also were significantly greater than those observed in healthy controls. Synchronously, positive significant correlations between salivary GR concentration and clinical parameters were observed. After binary logistic regression analysis, both GR salivary levels \u226515.38 and \u226524.20 mU\/mL were associated independently with CP and AgP, respectively. A significant interaction effect was also detected between increased GR salivary concentration and aging in the CP group.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Increased GR salivary concentration may be a strong\/independent prognostic indicator of the amount and extent of oxidative stress\u2010induced periodontal damage in both CP and AgP. Likewise, saliva samples might reflect an interactive effect of GR levels associated with the aging\u2010related cumulative characteristics of periodontal damage in CP.<\/jats:p>","DOI":"10.1902\/jop.2016.150618","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T14:42:10Z","timestamp":1452955330000},"page":"716-724","source":"Crossref","is-referenced-by-count":11,"title":["Influence of Periodontal Clinical Status on Salivary Levels of Glutathione Reductase"],"prefix":"10.1002","volume":"87","author":[{"given":"Y\u00e9sica Alejandra","family":"Villa\u2010Correa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Mar\u00eda","family":"Isaza\u2010Guzm\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio 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