{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:29:10Z","timestamp":1787023750008,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1130570"],"award-info":[{"award-number":["1130570"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CONICYT\u2010PCHA\/National Magister\/2013\u201022130172"],"award-info":[{"award-number":["CONICYT\u2010PCHA\/National Magister\/2013\u201022130172"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Probiotics are living microorganisms that provide beneficial effects for the host when administered in proper quantities. The aim of this double\u2010masked placebo\u2010controlled parallel\u2010arm randomized clinical trial is to evaluate the clinical effects of a\n                    <jats:italic>Lactobacillus rhamnosus<\/jats:italic>\n                    SP1\u2010containing probiotic sachet as an adjunct to non\u2010surgical therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Twenty\u2010eight systemically healthy volunteers with chronic periodontitis were recruited and monitored clinically at baseline and 3, 6, 9, and 12 months after therapy. Clinical parameters measured included plaque accumulation, bleeding on probing, probing depths (PDs), and clinical attachment loss. Patients received non\u2010surgical therapy, including scaling and root planing (SRP), and were assigned randomly to a test (SRP + probiotic, n = 14) or control (SRP + placebo, n = 14) group. The intake, once a day for 3 months, of an\n                    <jats:italic>L. rhamnosus<\/jats:italic>\n                    SP1 probiotic sachet commenced after the last session of SRP.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Both test and control groups showed improvements in clinical parameters at all time points evaluated. However, the test group showed greater reductions in PD than the control. Also, at initial visits and after 1\u2010year follow\u2010up, the test group showed a statistically significant reduction in the number of participants with PD \u22656 mm, indicating a reduced need for surgery, in contrast to the placebo group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The results of this trial indicate that oral administration of\n                    <jats:italic>L. rhamnosus<\/jats:italic>\n                    SP1 resulted in similar clinical improvements compared with SRP alone.\n                  <\/jats:p>","DOI":"10.1902\/jop.2016.150665","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T16:51:59Z","timestamp":1459183919000},"page":"944-952","source":"Crossref","is-referenced-by-count":96,"title":["Clinical Effects of\n                    <i>Lactobacillus rhamnosus<\/i>\n                    in Non\u2010Surgical Treatment of Chronic Periodontitis: A Randomized Placebo\u2010Controlled Trial With 1\u2010Year Follow\u2010Up"],"prefix":"10.1002","volume":"87","author":[{"given":"Alicia","family":"Morales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Carvajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Godoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Cabello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Garcia\u2010Sesnich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anilei","family":"Hoare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia I.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Gamonal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2013.0112"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-7325.1989.tb02014.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2012.00449.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.1998.tb00467.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100148"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290104.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.7.1033"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00192.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2007.00403.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12075"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130142"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00191.x"},{"key":"e_1_2_7_14_1","volume-title":"Probiotics in Food: Health and Nutritional Properties and Guidelines for Evaluation","author":"Food and Agriculture Organization of the United Nations. World Health Organization","year":"2006"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2011.03132.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.9.5308-5314.2004"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00305.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00017285-199611001-00002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2014.08.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140612"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01392.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01306.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12387"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12155"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v2i0.5344"},{"key":"e_1_2_7_26_1","first-page":"55","article-title":"Decreased gum bleeding and reduced gingivitis by the probiotic Lactobacillus reuteri","volume":"30","author":"Krasse P","year":"2006","journal-title":"Swed Dent J"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1221-6"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-0990-7"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2015.03.002"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00786.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01766.x"},{"key":"e_1_2_7_32_1","first-page":"7","article-title":"Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT)","volume":"1","author":"Lang NP","year":"2003","journal-title":"Oral Health Prev Dent"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2002.21216.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70093-9"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199208000-00002"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1996.d01-258.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1995.tb11561.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1086\/523341"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00127.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2012.734404"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2016.150665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:39:28Z","timestamp":1760881168000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2016.150665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1902\/jop.2016.150665"],"URL":"https:\/\/doi.org\/10.1902\/jop.2016.150665","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]}}}