{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T07:30:24Z","timestamp":1777188624233,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Peroxisome proliferator\u2010activated receptor (PPAR)\u2010\u03b3 activation leads to suppression of production of a broad range of proinflammatory molecules. It plays a role in differentiation of trophoblasts and helps in normal placentation and formation of vascular exchange interface. Activation of nuclear factor\u2010kappa (NF\u2010\u03ba) B triggers proinflammatory molecules inducing abnormal placentation and premature labor. This study aims to explore expression of PPAR\u2010\u03b3 and NF\u2010\u03baB in placentas of women with periodontitis\u2010associated preeclampsia compared with that in normotensive pregnant women.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Fifty pregnant women were included. Twenty\u2010five were controls (normotensive pregnant women) and 25 were pregnant women with preeclampsia, including those with gestational hypertension. Demographic data, pregnancy characteristics, and periodontal parameters were recorded, including: 1) plaque index; 2) gingival index; 3) bleeding on probing (BOP); 4) probing depth; and 5) attachment loss (AL). Placental tissue samples were collected from both groups and analyzed to quantify expression of PPAR\u2010\u03b3 and NF\u2010\u03baB using real\u2010time polymerase chain reaction.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> BOP and AL were significantly higher in pregnant women with preeclampsia compared with normotensive pregnant women (<jats:italic>P<\/jats:italic> &lt;0.05). Expression of PPAR\u2010\u03b3 was downregulated in patients with preeclampsia compared with that of healthy normotensive patients, which was statistically significant (<jats:italic>P<\/jats:italic> &lt;0.05), whereas NF\u2010\u03baB was significantly activated (<jats:italic>P<\/jats:italic> &lt;0.05) in pregnant women with preeclampsia compared with normotensive pregnant women.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Higher periodontal disease prevalence is found among pregnant women with preeclampsia, with increased percentage of sites with BOP and greater AL. This study provides novel information on host response to systemic inflammation induced by periodontal pathogens through mechanisms involving downregulation of PPAR\u2010\u03b3 and increased activation of NF\u2010\u03baB.<\/jats:p>","DOI":"10.1902\/jop.2016.150677","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T12:01:51Z","timestamp":1463140911000},"page":"962-970","source":"Crossref","is-referenced-by-count":14,"title":["Evidence Linking the Role of Placental Expressions of Peroxisome Proliferator\u2010Activated Receptor\u2010\u03b3 and Nuclear Factor\u2010Kappa B in the Pathogenesis of Preeclampsia Associated With Periodontitis"],"prefix":"10.1002","volume":"87","author":[{"given":"Jaideep","family":"Mahendra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prathahini 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