{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:45:28Z","timestamp":1787697928199,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["UO1 DE018902"],"award-info":[{"award-number":["UO1 DE018902"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["U01 DE018886"],"award-info":[{"award-number":["U01 DE018886"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The present study evaluates effects of non\u2010surgical periodontal treatment on serum biomarkers in patients with type 2 diabetes mellitus (t2DM) and chronic periodontitis who participated in the Diabetes and Periodontal Therapy Trial (DPTT); and associations among diabetes markers, serum biomarkers, and periodontal measures in these patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> DPTT participants randomized to receive immediate or delayed non\u2010surgical periodontal therapy were evaluated at baseline and 6 months. Serum samples from 475 participants with 6\u2010month data were analyzed for the following biomarkers: 1) high sensitivity C\u2010reactive protein; 2) E\u2010selectin; 3) tumor necrosis factor (TNF)\u2010\u03b1; 4) vascular cell adhesion molecule (VCAM); 5) interleukin (IL)\u20106; 6) IL\u20108; 7) intercellular adhesion molecule; and 8) IL\u201010. Changes in biomarker levels from baseline and correlations among biomarker levels and clinical findings were analyzed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> No differences between treatment and control groups were observed for any biomarkers at baseline or 6 months (<jats:italic>P<\/jats:italic> &gt;0.05 for all variables). VCAM levels increased by an average (standard deviation) of 17.9 (99.5); ng\/mL (<jats:italic>P<\/jats:italic> = 0.006) and E\u2010selectin decreased by 2.33 (16.08) ng\/mL (<jats:italic>P<\/jats:italic> = 0.03) in the treatment group after 6 months. E\u2010selectin levels were significantly correlated with DM\u2010related variables (hemoglobin A1c [HbA1c] and fasting glucose) at baseline and with 6\u2010month change in both groups; no significant correlations were found among periodontal clinical parameters and serum biomarkers or DM\u2010related variables. Neither HbA1c or body mass index varied during the study period in either study group.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Non\u2010surgical periodontal therapy and periodontal disease severity were not associated with significant changes in serum biomarkers in DPTT participants during the 6\u2010month follow\u2010up. Correlations among changes in E\u2010selectin, IL\u20106, and DM\u2010related variables suggest that t2DM may be the primary driver of systemic inflammation in these patients.<\/jats:p>","DOI":"10.1902\/jop.2016.150727","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T03:35:57Z","timestamp":1461555357000},"page":"900-913","source":"Crossref","is-referenced-by-count":44,"title":["Systemic Inflammatory Biomarkers and Their Association With Periodontal and Diabetes\u2010Related Factors in the Diabetes and Periodontal Therapy Trial, A Randomized Controlled Trial"],"prefix":"10.1002","volume":"87","author":[{"given":"Maria L.","family":"Geisinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan S.","family":"Michalowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elinor","family":"Schoenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Gelato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Engebretson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Hyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-S005"},{"key":"e_1_2_7_3_1","unstructured":"Centers for Disease Control and Prevention.2014National Diabetes Statistics Report. 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