{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:09:28Z","timestamp":1786968568227,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Polymorphisms in the immunoglobulin G Fc receptor II (FcGR) and tumor necrosis factor\u2010\u03b1 (<jats:italic>TNFA<\/jats:italic>) genes are known to influence pathogenesis and severity of several inflammatory conditions. Association of FcGR and <jats:italic>TNFA<\/jats:italic> gene polymorphisms with chronic periodontitis (CP) susceptibility has been found to be diverse among different ethnic populations. Objectives of the present study are to determine association of functional single nucleotide polymorphisms (SNPs) in FcGR and <jats:italic>TNF\u2010<\/jats:italic>\u03b1 genes with CP susceptibility in a cohort from South India.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Polymorphisms of: 1) <jats:italic>FCGR2A<\/jats:italic> 131His\/Arg (rs1801274); 2) <jats:italic>FCGR2B<\/jats:italic> 232Ile\/Thr (rs1050501); 3) <jats:italic>TNFA<\/jats:italic> \u20101031T\/C (rs1799964); and 4) <jats:italic>TNFA<\/jats:italic> \u2010863C\/A (rs1800630) were analyzed among patients with healthy gingiva (n = 176) and patients with CP (n = 177). Genotyping was performed using allele\u2010specific real\u2010time polymerase chain reaction assay. Association between CP and SNPs was examined by multivariable logistic regression analysis with adjustment for: 1) age; 2) sex; and 3) oral hygiene index (OHI). Epistatic interaction between FcGR polymorphisms and interleukin 1B (<jats:italic>IL1B)<\/jats:italic> +3954C\/T (rs1143634) was assessed using multifactorial dimensionality reduction analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Among four SNPs analyzed, only <jats:italic>FCGR2A<\/jats:italic> 131His\/Arg showed significant association with CP in a dominant model (odds ratio: 1.6; 95% confidence interval: 1.028 to 2.530). This significance disappeared after correcting for multiple comparisons using Bonferroni analysis, or after adjusting for age, sex, and OHI. A significant redundant interaction between <jats:italic>IL1B<\/jats:italic> +3954 C\/T and <jats:italic>FCGR2A<\/jats:italic> 131His\/Arg was observed.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Study results suggest the variant form of the SNP in <jats:italic>FCGR2A<\/jats:italic> 131His\/Arg, <jats:italic>FCGR2B<\/jats:italic> 232Ile\/Thr, <jats:italic>TNFA<\/jats:italic> \u20101031T\/C, and <jats:italic>TNFA<\/jats:italic> \u2010863C\/A are not associated with CP susceptibility in the selected cohort from South India.<\/jats:p>","DOI":"10.1902\/jop.2016.150743","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T03:32:41Z","timestamp":1460345561000},"page":"914-922","source":"Crossref","is-referenced-by-count":8,"title":["Polymorphic Regions in Fc Gamma Receptor and Tumor Necrosis Factor\u2010\u03b1 Genes and Susceptibility to Chronic Periodontitis in a Cohort From South 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