{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T12:50:08Z","timestamp":1777121408163,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Because peri\u2010implant mucositis may progress to peri\u2010implantitis, effective treatment resulting in resolution of inflammation could prevent peri\u2010implantitis. Current treatment protocols for this condition are still unpredictable. The purpose of this study is to analyze efficacy of non\u2010surgical treatment for patients with peri\u2010implant mucositis during a 6\u2010month follow\u2010up period.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This controlled, randomized, double\u2010masked clinical trial included 37 patients diagnosed with peri\u2010implant mucositis, randomly assigned into test group (basic periodontal therapy + 0.12% chlorhexidine) with 61 implants; and control group (basic periodontal therapy + placebo) with 58 implants. Therapy consisted of adaptation of the full\u2010mouth scaling and root planing protocol. Clinical parameters of visible plaque index (VPI), gingival bleeding index (GBI), probing depth (PD), and bleeding on probing (BOP) were measured in implants and were evaluated at baseline and at 1, 3, and 6 months post\u2010therapy. Data were analyzed using the split\u2010plot analysis of variance and \u03c7<jats:sup>2<\/jats:sup> tests with a significance level of 5%.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Intragroup analysis showed that VPI, GBI, PD, and BOP presented statistically significant improvements compared with baseline. No statistically significant differences were found between the test and control groups at any time.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Both isolated mechanical therapy and its association with 0.12% chlorhexidine mouthwash reduced peri\u2010implant mucositis. Therefore, 0.12% of chlorhexidine was not more effective than placebo.<\/jats:p>","DOI":"10.1902\/jop.2016.160144","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T05:20:47Z","timestamp":1467955247000},"page":"1305-1313","source":"Crossref","is-referenced-by-count":61,"title":["Efficacy of 0.12% Chlorhexidine Gluconate for Non\u2010Surgical Treatment of Peri\u2010Implant Mucositis"],"prefix":"10.1002","volume":"87","author":[{"given":"Karyna M.","family":"Menezes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson N.","family":"Fernandes\u2010Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinaldo D.","family":"Silva\u2010Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia S.","family":"Calderon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno C.V.","family":"Gurgel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1708-8208.2007.00081.x","article-title":"Implant treatment of patients with edentulous jaws: A 20\u2010year follow\u2010up","volume":"10","author":"Astrand P","year":"2008","journal-title":"Clin Implant Dent Relat Res"},{"key":"e_1_2_7_3_1","first-page":"602","article-title":"Implant treatment in the edentulous mandible: A prospective study on Br\u00e5nemark system implants over more than 20 years","volume":"16","author":"Ekelund JA","year":"2003","journal-title":"Int J Prosthodont"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2006.00003.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01283.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130101.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100176"},{"key":"e_1_2_7_8_1","first-page":"153","article-title":"Peri\u2010implant bone loss caused by occlusal overload: Repair of the peri\u2010implant defect following correction of the traumatic occlusion. 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