{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:15:07Z","timestamp":1789528507458,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["78443"],"award-info":[{"award-number":["78443"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["1266053"],"award-info":[{"award-number":["1266053"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005634","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riseura Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005609","name":"Turun Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005609","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Interleukin (IL)\u201023\u2010induced T helper (Th) 17 pathway is involved in the pathogenesis of periodontal disease. This study\u2019s aim is to determine levels of IL\u20101\u03b2, IL\u201017A, IL\u201023, and lipopolysaccharide (LPS) in saliva, and to examine whether their salivary concentrations are associated with periodontal health status.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Saliva samples originated from 220 participants; 76 had generalized periodontitis (GP) and 65 had localized periodontitis (LP), whereas 79 without periodontitis were used as controls. Cytokine analyses were performed by a flow cytometry\u2013based technique and LPS analyses from pellet by commercially optimized assay coupled with chromogenic substrate.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Salivary concentrations of IL\u201017A and IL\u201023 were elevated significantly in patients with LP compared with controls and patients with GP. Salivary IL\u20101\u03b2 concentrations were significantly higher in patients with GP than in patients with LP, whereas no difference was found between LP and control groups. Significant correlation was found between concentrations of IL\u201017A and IL\u201023 or IL\u20101\u03b2. LPS concentrations did not have significant associations with any of the tested ILs.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Elevated salivary IL\u20101\u03b2 concentrations are related to GP, whereas distinct elevation and reduction profiles of IL\u201017A and IL\u201023 are detected in saliva of patients with LP and GP.<\/jats:p>","DOI":"10.1902\/jop.2016.160146","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T09:49:08Z","timestamp":1471600148000},"page":"1484-1491","source":"Crossref","is-referenced-by-count":59,"title":["Salivary Concentrations of Interleukin (IL)\u20101\u03b2, IL\u201017A, and IL\u201023 Vary in Relation to Periodontal Status"],"prefix":"10.1002","volume":"87","author":[{"given":"Joonas","family":"Liukkonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulvi 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