{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:56:32Z","timestamp":1781362592973,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The authors have previously reported development of a novel immunochromatographic device (DK13\u2010PG\u2010001) for specific detection of <jats:italic>Porphyromonas gingivalis<\/jats:italic> (<jats:italic>Pg<\/jats:italic>). In this study, clinical usefulness of the detection device during periodontal therapy is presented.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The multicenter study was conducted with 62 patients contributing 118 periodontitis sites with probing depth (PD) of 4 to 9 mm. Subgingival plaque samples were used for detection of <jats:italic>Pg<\/jats:italic> by DK13\u2010PG\u2010001 and the PCR\u2010invader method at: 1) baseline (BL); 2) reevaluation (RE; after scaling and root planing); and 3) final evaluation (FE; after local drug delivery system). Periodontal examinations were performed concurrently with the test for <jats:italic>Pg<\/jats:italic> detection. Plasma immunoglobulin G (IgG) titers against <jats:italic>Pg<\/jats:italic> were also determined in patients using an enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> DK13\u2010PG\u2010001 score and number of <jats:italic>Pg<\/jats:italic> by the PCR\u2010invader method showed a strong correlation (<jats:italic>r<\/jats:italic> = 0.862) at three stages during periodontal therapy (n = 354). High sensitivity and specificity of DK13\u2010PG\u2010001, in comparison with the PCR\u2010invader method, were shown. A significant correlation was found among device score, number of <jats:italic>Pg<\/jats:italic> by the PCR\u2010invader method, and PD and clinical attachment level at BL and RE. Plasma IgG titers against <jats:italic>Pg<\/jats:italic> were significantly reduced at FE in comparison with BL. Weak but significant correlations between IgG titers and device scores were shown at BL and FE.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Results suggest the DK13\u2010PG\u2010001 device is a useful tool for detection of <jats:italic>Pg<\/jats:italic> in dental offices and can aid clinical evaluation of the extent of periodontitis and therapeutic efficacy.<\/jats:p>","DOI":"10.1902\/jop.2016.160147","type":"journal-article","created":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T22:08:12Z","timestamp":1467151692000},"page":"1238-1247","source":"Crossref","is-referenced-by-count":10,"title":["Clinical Usefulness of Novel Immunochromatographic Detection Device for <i>Porphyromonas gingivalis<\/i> in Evaluating Effects of Scaling and Root Planing and Local Antimicrobial 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