{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:40:23Z","timestamp":1790487623284,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study evaluates levels of matrix metalloproteinase (MMP)\u20108, MMP\u20109, and tissue inhibitor of MP\u20101 (TIMP\u20101) in biofluids of women with gestational diabetes mellitus (GDM) and systemically healthy counterparts with different statuses of periodontal health.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Seventy\u2010one women with GDM and gingivitis (Gg), 30 women with GDM and healthy periodontium (Gh), 28 systemically and periodontally healthy women (Hh), and 37 systemically healthy women with gingivitis (Hg) were evaluated. MMP\u20108, MMP\u20109, and TIMP\u20101 levels were determined in gingival crevicular fluid (GCF), saliva, and serum by immunofluorometric and enzyme\u2010linked immunosorbent assays. Full\u2010mouth clinical periodontal parameters were recorded.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> GCF and serum MMP\u20108 concentrations, serum MMP\u20109 concentrations, and serum MMP\u20108\/MMP\u20101 and MMP\u20109\/MMP\u20101 molar ratios were significantly higher in Gg compared with Hg group (<jats:italic>P<\/jats:italic> &lt;0.05). Serum MMP\u20108 levels and salivary TIMP\u20101 levels were higher in Gh compared with Hg group (<jats:italic>P<\/jats:italic> &lt;0.05) whereas salivary MMP\u20108\/TIMP\u20101 molar ratio was lower in Gh compared with Hg group (<jats:italic>P<\/jats:italic> &lt;0.05). Elevated concentrations of GCF MMP\u20108 and MMP\u20109 were found in Gg compared with Gh group (<jats:italic>P<\/jats:italic> &lt;0.05). Significant correlations were found between local levels of biomarkers and clinical periodontal parameters in only GDM group.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> GDM may modulate both local and circulating levels of MMP\u20108 especially when associated with gingivitis.<\/jats:p>","DOI":"10.1902\/jop.2016.160158","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T11:20:20Z","timestamp":1476962420000},"page":"289-297","source":"Crossref","is-referenced-by-count":17,"title":["Proteolytic Mediators in Gestational Diabetes Mellitus and 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