{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:31:51Z","timestamp":1789810311730,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this systematic review is to evaluate whether use of local or systemic antimicrobials would improve clinical results of non\u2010surgical periodontal therapy for smokers with chronic periodontitis (CP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Medical Literature Analysis and Retrieval System Online, Excerpta Medica Database, and The Cochrane Central Register of Controlled Trials were searched up to and including March 2016. Randomized clinical trials of duration of at least 6 months were included if they reported on treatment of smokers (\u226510 cigarettes per day for minimum 12 months) with CP with non\u2010surgical periodontal therapy either alone or associated with local or systemic antimicrobials. Random\u2010effects meta\u2010analyses were undertaken to evaluate mean differences in probing depth (PD) and clinical attachment level (CAL).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Of 108 potentially eligible articles, seven were included. Most individual studies (75%) testing locally delivered antibiotics reported that smokers benefited from this treatment approach. Pooled estimates found additional PD reduction of 0.81 mm (<jats:italic>P<\/jats:italic> = 0.01) and CAL gain of 0.91 mm (<jats:italic>P<\/jats:italic> = 0.01) at sites with baseline PD \u22655 mm. Conversely, meta\u2010analysis on systemic use of antimicrobials failed to detect significant differences in mean changes from baseline, and only one trial supported their use.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> In smokers with CP, adjunctive use of local antimicrobials improved efficacy of non\u2010surgical periodontal therapy in reducing PD and improving CAL at sites presenting PD \u22655 mm before treatment. Current evidence does not demonstrate similar gains when scaling and root planing plus systemic antimicrobial\/antibiotics were associated with therapy.<\/jats:p>","DOI":"10.1902\/jop.2016.160268","type":"journal-article","created":{"date-parts":[[2016,8,6]],"date-time":"2016-08-06T10:40:23Z","timestamp":1470480023000},"page":"1320-1332","source":"Crossref","is-referenced-by-count":36,"title":["Efficacy of Local and Systemic Antimicrobials in the Non\u2010Surgical Treatment of Smokers With Chronic Periodontitis: A Systematic Review"],"prefix":"10.1002","volume":"87","author":[{"given":"Leandro","family":"Chambrone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silie","family":"Arboleda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maritza","family":"Serna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria In\u00e9s","family":"Lafaurie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2009.00544.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080213"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.291107.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01682.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140430"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2075"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00822.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00786.x"},{"key":"e_1_2_7_10_1","first-page":"178","volume-title":"Carranza\u2019s Clinical Periodontology","author":"Preshaw PM","year":"2014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2007.00212.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.2.196"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02444.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01587.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260607.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2004.03793.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2009.0158"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12106"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01371.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2011.570230"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060472"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110625"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12427"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2015.01.028"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00375.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.3.426"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.3.464"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260305.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01058.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100192"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"e_1_2_7_32_1","unstructured":"HigginsJPT GreenS.Cochrane Handbook for Systematic Reviews of InterventionsVersion 5.0.1 [updated September 2011]. 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