{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:07:48Z","timestamp":1784257668314,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this split\u2010mouth study is to compare long\u2010term (18 to 35 years) periodontal conditions of sites treated with gingival augmentation procedures (GAPs) and untreated homologous contralateral sites.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty\u2010seven patients with 64 sites (test group), with lack of attached gingiva associated with recessions, were treated with marginal or submarginal free gingival grafts. Sixty\u2010four contralateral homologous sites (control group), with or without gingival recession (GR) and with attached gingiva, were left untreated. Patients were recalled every 4 to 6 months during follow\u2010up period. GR depth, keratinized tissue (KT) width, and probing depth were measured at baseline (T<jats:sub>0<\/jats:sub>), 1 year after surgery (T<jats:sub>1<\/jats:sub>), during follow\u2010up (10 to 27 years, T<jats:sub>2<\/jats:sub>), and at the end of the follow\u2010up period (18 to 35 years, T<jats:sub>3<\/jats:sub>). Multilevel and regression analyses were conducted.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> At the end of T<jats:sub>3<\/jats:sub>, 83% of the 64 treated sites showed recession reduction (RecRed), whereas 48% of the 64 untreated sites experienced increase in recession. Treated sites ended with gingival margin (GM) 1.7 mm (<jats:italic>P<\/jats:italic> = 0.01) more coronal and KT 3.3 mm (<jats:italic>P<\/jats:italic> &lt;0.001) wider than untreated sites. In grafted sites, KT at T<jats:sub>3<\/jats:sub> remained stable compared with T<jats:sub>1<\/jats:sub> value (4.1 mm, <jats:italic>P<\/jats:italic> &lt;0.001).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Sites treated with GAPs resulted in coronal displacement of GM with RecRed up to complete root coverage, whereas contralateral untreated sites showed a tendency to increase in existing recession or develop new recession during the 18\u2010 to 35\u2010year follow\u2010up.<\/jats:p>","DOI":"10.1902\/jop.2016.160284","type":"journal-article","created":{"date-parts":[[2016,8,13]],"date-time":"2016-08-13T09:13:21Z","timestamp":1471079601000},"page":"1371-1378","source":"Crossref","is-referenced-by-count":85,"title":["Periodontal Conditions of Sites Treated With Gingival Augmentation Surgery Compared With Untreated Contralateral Homologous Sites: An 18\u2010 to 35\u2010Year Long\u2010Term Study"],"prefix":"10.1002","volume":"87","author":[{"given":"Giancarlo","family":"Agudio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierpaolo","family":"Cortellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Buti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanpaolo","family":"Pini Prato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb02208.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb01275.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1977.tb02273.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.10.623"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12275"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00278.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.702"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.130684"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140377"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1982.53.6.349"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1985.tb00938.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1980.51.5.274"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070414"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090122"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150625"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_2_7_18_1","volume-title":"Multilevel Statistical Models","author":"Goldstein H","year":"2003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1980.51.12.681"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01896.x"},{"key":"e_1_2_7_21_1","first-page":"404","article-title":"Strip gingival autograft used to correct mucogingival problems around implants","volume":"15","author":"Han TJ","year":"1995","journal-title":"Int J Periodontics Restorative Dent"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2016.160284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:44:45Z","timestamp":1760863485000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2016.160284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1902\/jop.2016.160284"],"URL":"https:\/\/doi.org\/10.1902\/jop.2016.160284","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}