{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:07:33Z","timestamp":1790208453312,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    This study evaluates periodontal conditions and microbiologic findings and their influence on rheumatologic disease parameters in patients with rheumatoid arthritis (RA).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    One hundred and sixty\u2010eight patients with RA were included. A healthy control group (HC, n = 168) was composed according to age, sex, and smoking habits. Rheumatologic data (duration of illness, Disease Activity Score 28, rheumatic factor [RF], anti\u2010cyclic citrullinated peptide [aCCP], medications) were extracted from patients\u2019 records. Dental examination included: 1) dental findings (decayed, missing, and\/or filled adult teeth [DMF\u2010T] index); 2) gingival inflammation (papillary bleeding index [PBI]); and 3) periodontal status (probing depth [PD], attachment loss [AL]). Periodontal condition was classified as healthy\/mild, moderate, or severe periodontitis. Subgingival biofilm was analyzed regarding 11 periodontopathogenic bacteria. Statistical analyses included: 1) Kolmogorov\u2013Smirnov test; 2) Mann\u2013Whitney\n                    <jats:italic>U<\/jats:italic>\n                    test; 3) Pearson \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    test; 4) Kruskal\u2013Wallis test; and 5) regression analysis; level of significance \u03b1 = 5%.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Mean DMF\u2010T was significantly higher in patients with RA (19.3 \u00b1 4.8) than in HC group (16.9 \u00b1 5.8), especially owing to number of missing teeth (RA = 6.0 \u00b1 5.4, HC = 3.1 \u00b1 3.3;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01). Patients with RA had a significantly higher proportion of increased PD (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01) and AL compared with HC group (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01). Moderate to severe periodontitis was noted in 98% of patients with RA and 82% of the HC group (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01). RF\u2010positive patients with RA suffered from worse periodontal conditions than RF\u2010negative patients (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.01). Age, PBI, and presence of\n                    <jats:italic>Treponema denticola<\/jats:italic>\n                    (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.03) are related to periodontal condition in patients with RA. Although not statistically significant,\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    and\n                    <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    occur in higher concentrations more often in aCCP\u2010positive patients with RA (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.06).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Patients with RA had worse periodontal conditions than HC participants. Although a trend for higher\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    and\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    concentrations in aCCP\u2010positive patients with RA was found, importance of periodontal pathogenic bacteria and rheumatoid parameters in the interrelationship between periodontitis and RA remains unclear.\n                  <\/jats:p>","DOI":"10.1902\/jop.2016.160355","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T09:03:04Z","timestamp":1479459784000},"page":"368-379","source":"Crossref","is-referenced-by-count":62,"title":["Cross\u2010Sectional Evaluation of Periodontal Status and Microbiologic and Rheumatoid Parameters in a Large Cohort of Patients With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"88","author":[{"given":"Jan","family":"Schmickler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Rupprecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susann","family":"Patschan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Patschan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard A.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Haak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer F.","family":"Mausberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schmalz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Kottmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Ziebolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/259074"},{"key":"e_1_2_7_3_1","first-page":"609","article-title":"Rheumatoid arthritis and periodontitis \u2010 Inflammatory and infectious connections. 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