{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:35:01Z","timestamp":1773088501117,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Use of statins on adult patients with chronic periodontitis shows a positive effect on their periodontal status. However, effect of locally delivered statins on periodontal treatment has not yet been systematically analyzed. Hence, the present systematic review and meta\u2010analysis aims to evaluate efficacy of statins on treating localized periodontal intrabony defects (IBDs).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> An electronic search of three databases (PubMed, Embase, and Cumulative Index to Nursing and Allied Health Literature) between January 1, 1965 and March 1, 2016, and a hand search of peer\u2010reviewed journals for relevant articles were performed. Controlled randomized clinical trials (RCTs) and prospective studies with data on comparison between adjunctive locally delivered statin use to mechanical scaling and root planing (SRP) and placebo in each group, with minimum 10 participants and follow\u2010up period of at least 6 months, were included.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Ten studies, eight RCTs and two prospective studies, were included. Each study included 15 to 105 patients between 25 and 55 years of age. Statistical results were recorded; weighted mean difference (WMD) and confidence interval (CI) were calculated; and meta\u2010analyses were performed for defect fill, probing depth (PD) reduction, and clinical attachment level (CAL) gain in both statin and placebo\/no treatment groups. Overall analysis of defect fill presented WMD of 1.37 mm (95% CI = 0.96 to 1.77; <jats:italic>P<\/jats:italic> &lt;0.0001), PD reduction presented WMD of 1.76 mm (95% CI = 1.04 to 2.47; <jats:italic>P<\/jats:italic> &lt;0.0001), and CAL gain presented WMD of 1.58 mm (95% CI = 0.89 to 2.28; <jats:italic>P<\/jats:italic> &lt;0.0001). However, comparison presented considerable heterogeneity among studies.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> This systematic review and meta\u2010analysis find that adjunctive use of locally delivered statins to mechanical SRP is beneficial to increasing bone fill percentage. Improved inflammatory and bleeding control as well as PD reduction and CAL gain are possible advantages to using these drugs in treating patients with periodontal IBDs.<\/jats:p>","DOI":"10.1902\/jop.2016.160384","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T10:15:07Z","timestamp":1477044907000},"page":"357-367","source":"Crossref","is-referenced-by-count":21,"title":["The Effect of Locally Delivered Statins on Treating Periodontal Intrabony Defects: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"88","author":[{"given":"Khaled","family":"Sinjab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouf","family":"Zimmo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010Hao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Pang","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lujain","family":"Shaikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2355"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1993.tb02108.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.1996.tb00845.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.068001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.79"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/343425a0"},{"key":"e_1_2_7_9_1","unstructured":"Medscape.100 Best\u2010selling most prescribed branded drugs through March. May 2015. Available at:http:\/\/www.medscape.com\/viewarticle\/844317#vp_1. Accessed April 15 2016."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2006.01.005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-008-0344-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm496"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.09.125"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-8-16"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0108064"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.94.403"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mca.0000078062.22445.60"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2004.11.012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2238"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)01297-3"},{"key":"e_1_2_7_21_1","first-page":"53","article-title":"Regulation of osteoclast differentiation by statins","volume":"3","author":"Grasser WA","year":"2003","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.2.295"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20074"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11.1861"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.SC0070184"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-64402010000300003"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500608"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/cap.2014.130084"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12564"},{"key":"e_1_2_7_30_1","unstructured":"HigginsJPT GreenS. Handbook for systematic reviews of interventions version 5.1. 0 [updated March 2011].The Cochrane Collaboration2011. Available at:http:\/\/handbook.cochrane.org\/. Accessed April 1 2016."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.72352"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00136"},{"key":"e_1_2_7_33_1","first-page":"75","article-title":"Evaluation of the relative efficacy of an allograft used alone and that in combination with simvastatin in the treatment of human periodontal infrabony defects: A clinical and radiological study","volume":"5","author":"Kinra P","year":"2010","journal-title":"J T U Med Sc"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090429"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110716"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110721"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12042"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140631"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150706"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150131"},{"key":"e_1_2_7_41_1","first-page":"70","article-title":"A clinical, radiological and IL\u20106 evaluation of subgingivally delivered simvastatin in the treatment of chronic periodontitis","volume":"4","author":"Rath A","year":"2012","journal-title":"Int J Drug Deliv"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1515\/dmpt-2015-0024"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-2-22"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMC.S4324"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01454-0"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18280"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2004.00299.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.08.010"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079903125002405"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12066"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-013-0358-6"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.192"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199040040-00007"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.5.265"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2006.01.005"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60716-8"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb01121.x"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2016.160384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:43:10Z","timestamp":1760866990000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2016.160384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1902\/jop.2016.160384"],"URL":"https:\/\/doi.org\/10.1902\/jop.2016.160384","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}