{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:37:04Z","timestamp":1760920624915,"version":"build-2065373602"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Controversy exists regarding possible correlation of periodontal disease with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Confounding factors may relate to stringency of inflammatory disease diagnosis and the effect of therapeutic intervention for RA on periodontal disease. These factors are investigated in this study.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty\u2010five individuals with documented RA (n = 15), spondyloarthropathy (n = 15), and calcium pyrophosphate deposition disease (CPPD) (n = 15), from the Hamann\u2013Todd collection of human skeletons compiled from 1912 to 1938, and 15 individuals contemporarily incorporated in the collection were examined for tooth loss, cavity occurrence, average and maximum lingual and buccal depth of space between tooth and bone, periosteal reaction, serpentine bone resorption, abscess formation, and root penetration of the bone surface and analyzed by analysis of variance.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Tooth loss was common, but actual number of teeth lost, cavity occurrence, average and maximum lingual and buccal depth of space between tooth and bone, periosteal reaction, serpentine grooving surrounding teeth (considered a sign of inflammation), abscess formation, and root exposure (penetration of bone surface) were indistinguishable among controls and individuals with RA, spondyloarthropathy, and CPPD.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Although many factors can affect periodontal disease, presence of inflammatory arthritis does not appear to be one of them. The implication is that dental disease was common in the general population and not necessarily associated with arthritis, at least before the advent of modern rheumatologic medications. As specific diagnosis did not affect prevalence, perhaps current prevalence controversy may relate to current intervention, a subject for further study.<\/jats:p>","DOI":"10.1902\/jop.2016.160422","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T05:41:02Z","timestamp":1478842862000},"page":"266-272","source":"Crossref","is-referenced-by-count":2,"title":["Correlation of Periodontal Disease With Inflammatory Arthritis in the Time Before Modern Medical Intervention"],"prefix":"10.1002","volume":"88","author":[{"given":"Bruce","family":"Rothschild","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34539"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.04.015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01776.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3106"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090309"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401221"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12315"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40496-014-0040-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40496-014-0038-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v4i0.11829"},{"key":"e_1_2_7_12_1","first-page":"70","article-title":"Association of periodontal disease and tooth loss with rheumatoid arthritis in the US population","volume":"35","author":"Pablo P","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.039172"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110321"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2012.42.3.67"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2066"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000300"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.097212"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110664"},{"issue":"13","key":"e_1_2_7_20_1","first-page":"S295","article-title":"Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis","volume":"18","author":"Gibofsky A","year":"2012","journal-title":"Am J Manag Care"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01714.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2974-2"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835fb8ec"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23177"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513483142"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-4-460"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.2.100"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330850202"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330820406"},{"key":"e_1_2_7_30_1","first-page":"557","article-title":"Calcium pyrophosphate deposition disease: Description in defleshed skeletons","volume":"10","author":"Rothschild BM","year":"1992","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330800406"},{"volume-title":"Skeletal Impact of Disease","year":"2006","author":"Rothschild BM","key":"e_1_2_7_32_1"},{"key":"e_1_2_7_33_1","first-page":"1","article-title":"Evidence from surface microscopy for recognition of fleshy and tendinous muscle insertion in extant vertebrate femora: Implications for muscle reconstruction in fossils","volume":"28","author":"Rothschild BM","year":"2015","journal-title":"Hist Biol"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22673"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00413.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-014-0408-9"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242008000100013"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2014.905"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2001.tb00267.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301970"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.121"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091323"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202701"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27552"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202726"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205385"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.134"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3180690616"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080447"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140194"},{"key":"e_1_2_7_51_1","first-page":"615","article-title":"An evaluation of the effect of dental foci of infection on health","volume":"42","author":"Easlick KA","year":"1951","journal-title":"J Am Dent Assoc"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2016.160422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:30:21Z","timestamp":1760877021000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2016.160422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1902\/jop.2016.160422"],"URL":"https:\/\/doi.org\/10.1902\/jop.2016.160422","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2017,3]]}}}