{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:58:57Z","timestamp":1791212337220,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study evaluates contributions of platelet\u2010rich fibrin (PRF) combined with conventional flap surgery on growth factor levels in gingival crevicular fluid (GCF) and periodontal healing.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010six patients (52 sites) with chronic periodontitis were treated either with autologous PRF with open flap debridement (OFD+PRF) or OFD alone. Growth factor levels in GCF at baseline and 2, 4, and 6 weeks after surgery were analyzed, and clinical parameters such as probing depth (PD), relative clinical attachment level (rCAL), and gingival margin level (GML) at baseline and 9 months after surgery were measured.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Mean PD reduction and rCAL gain were significantly greater in OFD+PRF sites than in OFD sites. Mean GML change was \u22120.38 + 0.10 mm in OFD sites and 0.11 + 0.08 mm in the test group; difference between the two groups was statistically significant (<jats:italic>P<\/jats:italic> &lt;0.05). Both groups demonstrated increased expression levels of fibroblast growth factor\u20102, transforming growth factor\u2010\u03b21, and platelet\u2010derived growth factor\u2010BB at 2 weeks compared with baseline, followed by reductions at 4 and 6 weeks. The OFD+PRF group showed significantly higher growth factor levels compared with the OFD group at 2 and 4 weeks.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> PRF membrane combined with OFD provides significantly higher GCF concentrations of angiogenic biomarkers for \u22482 to 4 weeks and better periodontal healing in terms of conventional flap sites.<\/jats:p>","DOI":"10.1902\/jop.2017.160485","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T09:36:33Z","timestamp":1493372193000},"page":"771-777","source":"Crossref","is-referenced-by-count":18,"title":["Advantages of Autologous Platelet\u2010Rich Fibrin Membrane on Gingival Crevicular Fluid Growth Factor Levels and Periodontal Healing: A Randomized Split\u2010Mouth Clinical 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