{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:34:28Z","timestamp":1789965268959,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21DE018438"],"award-info":[{"award-number":["R21DE018438"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA204113"],"award-info":[{"award-number":["R01CA204113"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["2009627047"],"award-info":[{"award-number":["2009627047"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study assesses the association between periodontal pathogen colonization and the potential risk of developing precancerous lesions of gastric cancer (PLGC) in a clinical setting.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Included were 35 newly diagnosed patients with PLGC and 70 age\u2010matched individuals without PLGC. A full\u2010mouth intraoral examination was performed to assess periodontal conditions. Stimulated whole saliva and pooled plaque samples were collected to evaluate colonization by <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Treponema denticola<\/jats:italic>, <jats:italic>Tannerella forsythia<\/jats:italic>, and <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> and to characterize oral microbial diversity in saliva and dental plaque.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Compared with the control group, patients with PLGC experienced higher prevalence of bleeding on probing (31.5% versus 22.4%; <jats:italic>P<\/jats:italic> &lt;0.05), higher levels of <jats:italic>T. denticola<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt;0.01) and <jats:italic>A. actinomycetemcomitans<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt;0.01), and less bacterial diversity in their saliva (<jats:italic>P<\/jats:italic> &lt;0.01). The final multivariate logistic regression model consisting of all key sociodemographic characteristics, oral health behavioral factors, and periodontal assessments revealed that elevated colonization with periodontal pathogens, specifically <jats:italic>T. forsythia, T. denticola<\/jats:italic>, and <jats:italic>A. actinomycetemcomitans<\/jats:italic>, decreased bacterial diversity in dental plaque, and not flossing teeth regularly was a significant predictor of increased risk of PLGC (<jats:italic>P<\/jats:italic> = 0.022).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Findings of the present study provide new evidence suggesting that periodontal pathogen burdens and bacterial diversity in the oral cavity are important factors contributing to a potentially increased risk of developing precancerous gastric lesions.<\/jats:p>","DOI":"10.1902\/jop.2017.160829","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T09:45:36Z","timestamp":1499075136000},"page":"1124-1134","source":"Crossref","is-referenced-by-count":51,"title":["Chronic Periodontal Disease, Periodontal Pathogen Colonization, and Increased Risk of Precancerous Gastric Lesions"],"prefix":"10.1002","volume":"88","author":[{"given":"Jinghua","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian R.","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Hays","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhleen","family":"Bedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0578"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i3.354"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2013.14"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510015430"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw028"},{"key":"e_1_2_8_8_1","first-page":"1191","article-title":"Lifestyle and gastric cancer: A case\u2010control study","volume":"5","author":"Watabe K","year":"1998","journal-title":"Oncol Rep"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12473"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2106"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc0081"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr284"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051604"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00317-06"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00174.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_8_18_1","first-page":"159","volume-title":"Oral Health of United States Adults; 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