{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:02:35Z","timestamp":1788793355006,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The role of keratinized tissue (KT) for maintenance of periodontal health has been debated for many years. This study assesses the long\u2010term \u201cbiologic remodeling\u201d of periodontal dimensions of teeth treated with free gingival grafts (FGGs) compared with adjacent\/untreated teeth.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Seventy\u2010four patients with at least one site showing absence or a reduced amount of attached gingiva associated with gingival recession (GR) at baseline were treated with FGGs in a private practice. Patient\/tooth\/site\u2010associated variables were recorded for each patient (treated and mesial\/distal adjacent teeth) at baseline (T<jats:sub>0<\/jats:sub>), 6 months after surgery (T<jats:sub>1<\/jats:sub>), during the follow up period (T<jats:sub>2<\/jats:sub>) (mean 15.3 years), and at the end of the follow\u2010up period (T<jats:sub>3<\/jats:sub>) over 25 years. Parametric, non\u2010parametric, and mixed effects logistic regression statistics were used throughout the study.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 182 teeth submitted to FGGs were compared with 247 untreated\/adjacent teeth. The majority of treated teeth (n = 152; 83.5%) showed GR depth (GRD) reduction (<jats:italic>P<\/jats:italic> &lt;0.001). Conversely, untreated\/adjacent teeth displayed GRD increase at T<jats:sub>3<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt;0.001). Statistically significant KT band contraction was also found at treated sites, whereas adjacent sites presented small clinical improvements (<jats:italic>P<\/jats:italic> &lt;0.001). The total root\u2010coverage esthetic score of the areas including treated and adjacent untreated teeth improved from T<jats:sub>2<\/jats:sub> to T<jats:sub>3<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt;0.001). Some independent variables, such as age, tooth type, and GRD at T<jats:sub>1<\/jats:sub> seem to influence GRD and KT changes over time.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Soft tissue augmentation procedures may modify the biologic remodeling of periodontal dimensions over time associated with aging. Use of FGGs may promote more favorable KT dimensions and improve marginal tissue recession.<\/jats:p>","DOI":"10.1902\/jop.2017.170010","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T11:50:33Z","timestamp":1490356233000},"page":"634-642","source":"Crossref","is-referenced-by-count":52,"title":["Biologic Remodeling of Periodontal Dimensions of Areas Treated With Gingival Augmentation Procedure: A 25\u2010Year Follow\u2010Up Observation"],"prefix":"10.1002","volume":"88","author":[{"given":"Giancarlo","family":"Agudio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Chambrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanpaolo","family":"Pini Prato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(59)90078-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1961.32.3.261"},{"key":"e_1_2_7_4_1","volume-title":"A Series of Lecture Notes on Periodontology","author":"Cohen DW","year":"1962"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1979.50.4.170"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12078"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1981.tb00997.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160284"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb01148.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.5.713"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070414"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080565"},{"key":"e_1_2_7_13_1","first-page":"603","article-title":"Esthetic evaluation of root coverage outcomes: A case series study","volume":"31","author":"Pini\u2010Prato G","year":"2011","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1978.49.10.513"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1982.53.6.349"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1976.47.10.574"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1980.51.12.681"},{"key":"e_1_2_7_19_1","first-page":"47","article-title":"Root coverage in a class IV recession defect achieved by creeping attachment: A case report","volume":"8","author":"Chambrone LA","year":"2006","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1976.tb00069.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1978.tb00169.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12130"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01896.x"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2017.170010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:57:42Z","timestamp":1760878662000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2017.170010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1902\/jop.2017.170010"],"URL":"https:\/\/doi.org\/10.1902\/jop.2017.170010","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}