{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:25:12Z","timestamp":1793060712184,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["5652247"],"award-info":[{"award-number":["5652247"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["57336341"],"award-info":[{"award-number":["57336341"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["5866432"],"award-info":[{"award-number":["5866432"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["6143476"],"award-info":[{"award-number":["6143476"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The objective of this cross\u2010sectional study is to investigate levels of salivary and serum matrix metalloproteinase (MMP)\u20109, myeloperoxidase (MPO), neutrophil elastase (NE), and MMP\u20109\/tissue inhibitor of MMP\u20101 (TIMP)\u20101 ratio in patients with polycystic ovary syndrome (PCOS) and systemically healthy controls in the presence or absence of gingivitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Serum and salivary levels of these biomarkers were evaluated in the following: 1) periodontally healthy women with PCOS (n = 45); 2) women with PCOS and gingivitis (n = 35); 3) systemically and periodontally healthy women (n = 25); and 4) systemically healthy women with gingivitis (n = 20). Enzyme\u2010linked immunosorbent assay was used to determine levels of these biomarkers. A full\u2010mouth clinical periodontal evaluation was performed for each patient.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Salivary MMP\u20109 and NE levels, as well as MMP\u20109\/TIMP\u20101 ratios, were higher in the systemically healthy women with gingivitis compared with periodontally healthy women with PCOS (<jats:italic>P<\/jats:italic> &lt;0.001; <jats:italic>P<\/jats:italic> &lt;0.01; and <jats:italic>P<\/jats:italic> &lt;0.0001, respectively). Serum MMP\u20109 and MPO levels were higher in women with PCOS and gingivitis compared with periodontally healthy women with PCOS (<jats:italic>P<\/jats:italic> &lt;0.05). Serum MMP\u20109 levels were lower in healthy women with gingivitis than systemically and periodontally healthy women or women with PCOS and gingivitis (<jats:italic>P<\/jats:italic> &lt;0.05). PCOS groups exhibited a positive correlation among clinical periodontal parameters and serum MMP\u20109 levels or salivary MPO, NE levels, and MMP\u20109\/MMP\u20101 ratio. Correlation was negative among clinical periodontal parameters and serum MMP\u20109 levels and MMP\u20109\/TIMP\u20101 ratio in systemically healthy patients (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The present findings emphasize that PCOS and gingival inflammation are associated with each other, as evidenced by salivary and serum levels of neutrophilic enzymes. This interaction may contribute to the perturbation of ovarian remodeling in PCOS.<\/jats:p>","DOI":"10.1902\/jop.2017.170043","type":"journal-article","created":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T11:08:19Z","timestamp":1497006499000},"page":"1145-1152","source":"Crossref","is-referenced-by-count":26,"title":["Gingival Inflammation and Salivary or Serum Granulocyte\u2010Secreted Enzymes in Patients With Polycystic Ovary 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