{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:19:06Z","timestamp":1760919546749,"version":"build-2065373602"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Despite well\u2010established evidence that cigarette smoking is the largest modifiable risk factor for periodontal disease and has many deleterious health effects, treatment of periodontal disease in smokers remains a challenge of periodontal therapy. A recent meta\u2010analysis revealed that adjunctive use of local delivery of antimicrobials, but not systemic antibiotic usage, with non\u2010surgical periodontal therapy resulted in improvement in clinical periodontal parameters. Further evaluation of the current literature reveals that host modulation therapy may also result in clinical benefit in smokers. These findings may be tied to the underlying pathophysiology of periodontal disease progression in smokers and suggest that focused therapies that target known mechanisms of action are critical to the success of proposed treatments.<\/jats:p>","DOI":"10.1902\/jop.2017.170098","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T09:39:57Z","timestamp":1493113197000},"page":"703-710","source":"Crossref","is-referenced-by-count":4,"title":["Commentary: Targeting Underlying Biologic Mechanisms in Selecting Adjunctive Therapies to Improve Periodontal Treatment in Smokers: A Commentary"],"prefix":"10.1002","volume":"88","author":[{"given":"Maria L.","family":"Geisinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaas C.","family":"Geurs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Ogdon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1997.0259"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.5.467"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb02229.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.5.666"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00285.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.1.43"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1990.tb01098.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02428.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.11.1355"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.30.3.649-655.1980"},{"key":"e_1_2_7_12_1","first-page":"178","volume-title":"Carranza\u2019s Clinical Periodontology","author":"Preshaw PM","year":"2014"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.2.196"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060472"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.4.550"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.3.628"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160268"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110600"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12019"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12111"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.3.426"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.3.464"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260305.x"},{"issue":"3","key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1532-3382(12)70015-5","article-title":"Adjunctive antibiotics with nonsurgical periodontal therapy improve the clinical outcome of chronic periodontitis in current smokers","volume":"12","author":"Albandar JM","year":"2012","journal-title":"J Evid Based Dent Pract"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100192"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12121"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2015.01.028"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/cap.2011.100008"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070375"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01058.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00728.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00663.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00696.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070165"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.8.1068"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.3.453"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100036"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070118"},{"key":"e_1_2_7_39_1","first-page":"5","article-title":"No evidence to support the use of low\u2010dose doxycycline as an adjunct to nonsurgical therapy in smokers","volume":"8","author":"Nierderman R","year":"2007","journal-title":"Evid Based Dent"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.4.521"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.5.743"},{"key":"e_1_2_7_42_1","first-page":"868","volume-title":"Periodontics: Medicine, Surgery, and Implants","author":"Grossi SG","year":"2004"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.3.260"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2001.49118.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01083.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110012"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700812"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080013"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050193"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1990.tb00923.x"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.7.762"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.1.106"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2012.01468.x"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060217"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070149"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12085"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2017.170098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:51:17Z","timestamp":1760863877000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2017.170098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1902\/jop.2017.170098"],"URL":"https:\/\/doi.org\/10.1902\/jop.2017.170098","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}