{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:06:22Z","timestamp":1791806782119,"version":"4.3.4"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This systematic review assesses microbiologic profiles of peri\u2010implantitis, periodontitis, and healthy implants based on studies that evaluated microbial biofilms and entire microbiomes to establish their similarities and differences.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The Medical Literature Analysis and Retrieval System Online via PubMed, Excerpta Medica Database, and Cochrane Central Register of Controlled Trials, were searched without language restrictions through July 30, 2016. Observational studies that evaluated microbial profiles or entire microbiomes of peri\u2010implantitis compared with healthy implants or periodontitis were considered eligible for inclusion. A descriptive summary was created to determine quantity of data and interstudy variations.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Of 126 potentially eligible articles, 26 were included in this study. Twenty\u2010one of these articles evaluated the microbiologic profile of peri\u2010implantitis versus healthy implants or periodontitis using conventional microbiologic techniques. Five articles evaluated the entire microbiome using genomic sequencing. Teeth with periodontitis, healthy implants, or implants with peri\u2010implantitis were colonized by periodontal microorganisms. <jats:italic>Porphyromonas gingivalis<\/jats:italic> and especially <jats:italic>Prevotella intermedius<\/jats:italic>\/<jats:italic>nigrescens<\/jats:italic> were often identified at peri\u2010implantitis sites. Peri\u2010implantitis sites were also colonized by uncultivable asaccharolytic anaerobic Gram\u2010positive rods and anaerobic Gram\u2010negative rods, which were not frequently identified in teeth with periodontitis or healthy implants. Opportunistic microorganisms were not found very frequently in peri\u2010implantitis sites.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Peri\u2010implantitis represents a heterogeneous mixed infection that includes periodontopathic microorganisms, uncultivable asaccharolytic anaerobic Gram\u2010positive rods and other uncultivable Gram\u2010negative rods, and, rarely, opportunistic microorganisms such as enteric rods and <jats:italic>Staphylococcus aureus.<\/jats:italic> Sequencing methods that evaluate the entire microbiome improve identification of microorganisms associated with peri\u2010implantitis.<\/jats:p>","DOI":"10.1902\/jop.2017.170123","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T03:31:46Z","timestamp":1497843106000},"page":"1066-1089","source":"Crossref","is-referenced-by-count":263,"title":["Microbiome and Microbial Biofilm Profiles of Peri\u2010Implantitis: A Systematic Review"],"prefix":"10.1002","volume":"88","author":[{"given":"Gloria In\u00e9s","family":"Lafaurie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Alejandra","family":"Sabogal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Marcela","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Victoria","family":"Rinc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Amparo","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamil Augusto","family":"Lesmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Chambrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514537828"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g5.2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12334"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12684"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.4149"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.134001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01837.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01674.x"},{"key":"e_1_2_7_10_1","first-page":"486","article-title":"Bacterial analysis of peri\u2010implantitis and chronic periodontitis in Iranian subjects","volume":"50","author":"Ebadian AR","year":"2012","journal-title":"Acta Med Iran"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12047"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160184"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.4150"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01378.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3182199348"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01194.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.3947"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12557"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01856.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v2i0.5104"},{"key":"e_1_2_7_21_1","unstructured":"WellsGA SheaB O'ConnellD et al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta\u2010analyses. 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