{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:42:08Z","timestamp":1790023328963,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/19473\u20106"],"award-info":[{"award-number":["2013\/19473\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Considering xenogeneic collagen matrix (CM) and enamel matrix derivative (EMD) characteristics, it is suggested that their combination could promote superior clinical outcomes in root coverage procedures. Thus, the aim of this parallel, double\u2010masked, dual\u2010center, randomized clinical trial is to evaluate clinical outcomes after treatment of localized gingival recession (GR) by a coronally advanced flap (CAF) combined with CM and\/or EMD.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Sixty\u2010eight patients presenting one Miller Class I or II GRs were randomly assigned to receive either CAF (n = 17); CAF + CM (n = 17); CAF + EMD (n = 17), or CAF + CM + EMD (n = 17). Recession height, probing depth, clinical attachment level, and keratinized tissue width and thickness were measured at baseline and 90 days and 6 months after surgery.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The obtained root coverage was 68.04% \u00b1 24.11% for CAF; 87.20% \u00b1 15.01% for CAF + CM; 88.77% \u00b1 20.66% for CAF + EMD; and 91.59% \u00b1 11.08% for CAF + CM + EMD after 6 months. Groups that received biomaterials showed greater values (<jats:italic>P<\/jats:italic> &lt;0.05). Complete root coverage (CRC) for CAF + EMD was 70.59%, significantly superior to CAF alone (23.53%); CAF + CM (52.94%), and CAF + CM + EMD (51.47%) (<jats:italic>P<\/jats:italic> &lt;0.05). Keratinized tissue thickness gain was significant only in CM\u2010treated groups (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The three approaches are superior to CAF alone for root coverage. EMD provides highest levels of CRC; however, the addition of CM increases gingival thickness. The combination approach does not seem justified.<\/jats:p>","DOI":"10.1902\/jop.2017.170126","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T11:00:35Z","timestamp":1501239635000},"page":"1309-1318","source":"Crossref","is-referenced-by-count":46,"title":["Xenogenous Collagen Matrix and\/or Enamel Matrix Derivative for Treatment of Localized Gingival Recessions: A Randomized Clinical Trial. Part I: Clinical Outcomes"],"prefix":"10.1002","volume":"88","author":[{"given":"Jo\u00e3o Paulo Menck","family":"Sangiorgio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Lucas da Silva","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Rocha dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Lima","family":"Fran\u00e7a\u2010Grohmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Corr\u00eaa Viana","family":"Casarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio Zaffalon","family":"Casati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro 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