{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:33:19Z","timestamp":1789065199338,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with polycystic ovary syndrome (PCOS), chronic periodontitis (CP) contributed to increased oxidative stress (OS), owing to an increase in serum and salivary 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine (8\u2010OHdG) and malondialdehyde (MDA) levels and a decrease in serum total antioxidant status (TAS) levels. The aim of the present study is to investigate salivary and serum 8\u2010OHdG and MDA levels as well as total antioxidant status (TAS) in females with CP and PCOS compared with healthy females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four groups, each consisting of 22 individuals, were: 1) women with both PCOS and CP (PCOSCP); 2) systemically healthy women with CP; 3) periodontally healthy women with PCOS (PCOSPH); and 4) periodontally and systemically healthy women (PH). Demographic and clinical periodontal parameters were measured. Oxidative parameters were evaluated in serum and salivary samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Salivary 8\u2010OHdG levels in the PCOSCP and CP groups were statistically higher than those in both the PCOSPH and the PH groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). There was no statistical difference between the PCOSCP, CP, and PCOSPH groups with regard to salivary MDA and TAS levels (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Highest serum 8\u2010OHdG and MDA levels and lowest serum TAS levels were seen in the PCOSCP group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Serum 8\u2010OHdG and MDA levels in the PCOSPH group were higher than those in both systemically healthy groups (PH and CP) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Salivary TAS levels were highest (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) in the PH group. There was no statistical difference between the CP and PCOSPH groups, but serum TAS levels were lower than those in the PH group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CP, which led to an increase in serum and salivary 8\u2010OHdG and MDA levels and a decrease in serum TAS levels in patients with PCOS, contributed to increased OS. This effect was more prominent in serum levels than in salivary levels.<\/jats:p><\/jats:sec>","DOI":"10.1902\/jop.2017.170129","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T04:18:58Z","timestamp":1503893938000},"page":"76-84","source":"Crossref","is-referenced-by-count":30,"title":["Evaluation of oxidative status in patients with chronic periodontitis and polycystic ovary syndrome: A cross\u2010sectional study"],"prefix":"10.1002","volume":"89","author":[{"given":"Ebru","family":"Saglam","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Bezmialem University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cenk Fatih","family":"Canakci","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saime Ozbek","family":"Sebin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrin","family":"Saruhan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Eskisehir Osmangazi University  Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Ingec","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Ataturk University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcmeyra","family":"Canakci","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Buhara Hospital  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Sezer","sequence":"additional","affiliation":[{"name":"Periodontology, Private Practice  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070605"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00760.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0402"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00689.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.51"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","unstructured":"Rotterdam ESHRE\/ASRM\u2010Sponsored PCOS Consensus Workshop Group.Revised 2003 consensus on diagnostic criteria and long\u2010term health risks related to polycystic ovary syndrome. 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