{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:26:41Z","timestamp":1790429201102,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005278","name":"Universidad de Antioquia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005278","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Emerging evidence suggests that activation of inflammasomes plays a central mechanism in pathogenesis of periodontitis. This study aims to compare salivary levels of nod\u2010like receptor family pyrin domain containing protein (NLRP) 3, apoptosis\u2010associated speck\u2010like protein containing a caspase recruitment domain (ASC), cysteine aspartase (caspase)\u20101, and interleukin (IL)\u20101\u03b2 from individuals with aggressive (AgP) or chronic periodontitis (CP) and healthy controls (HC), as well as elucidate its association with periodontal clinical status.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Saliva samples from individuals with CP (n = 75), AgP (n = 20), and HC (n = 69) were collected. Periodontal status was assessed by measurement of probing depth, clinical attachment level, and extent and severity of disease. Salivary levels of analytes were analyzed by enzyme\u2010linked immunosorbent assay. Association between biomarkers with CP or AgP was analyzed using multivariate binary logistic regression models.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Significantly higher levels of NLRP3, ASC, and IL\u20101\u03b2 were detected in periodontitis groups in comparison to the periodontally HC group. However, no significant differences were observed for caspase\u20101 levels between clinical groups, and only NLRP3 salivary concentration was significantly higher in AgP compared with CP patients. Also, positive significant correlations among NLRP3, ASC, and IL\u20101\u03b2 salivary concentrations and clinical parameters were observed. Logistic regression analyses revealed a strong\/independent association of NLRP3, ASC, and IL\u20101\u03b2 salivary levels with CP and AgP.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Although the concentration of caspase\u20101 in saliva samples makes its determination useless for detection of periodontal disease and\/or its severity, salivary levels of NLRP3, ASC, and IL\u20101\u03b2 may act as strong\/independent indicators of amount and extent of periodontal breakdown in both CP and AgP and could potentially be used for prevention and therapy of this group of diseases.\n                  <\/jats:p>","DOI":"10.1902\/jop.2017.170244","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T10:06:33Z","timestamp":1499681193000},"page":"1329-1338","source":"Crossref","is-referenced-by-count":83,"title":["Salivary Levels of NLRP3 Inflammasome\u2010Related Proteins as Potential Biomarkers of Periodontal Clinical Status"],"prefix":"10.1002","volume":"88","author":[{"given":"Diana M.","family":"Isaza\u2010Guzm\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica M.","family":"Medina\u2010Piedrah\u00edta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Guti\u00e9rrez\u2010Henao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio 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