{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:55:59Z","timestamp":1762955759589,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Trappin\u20102 is a potent biologically active serine protease inhibitor with anti\u2010inflammatory properties that has also been characterized as an \u201calarm anti\u2010protease.\u201d Although the importance of trappin\u20102 in several chronic infections has been demonstrated, its potential involvement in periodontitis remains undefined. This study aims to investigate salivary levels of trappin\u20102 and interleukin (IL)\u20101\u03b2 in periodontally healthy individuals and patients with gingivitis or generalized chronic periodontitis (CP) or aggressive periodontitis (GAgP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Whole unstimulated saliva samples were collected from 80 systemically healthy and non\u2010smoking individuals before full\u2010mouth periodontal examination. Trappin\u20102 and IL\u20101\u03b2 were analyzed by enzyme\u2010linked immunosorbent assay and reported as nanograms per milligram after calibration for total protein levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Correlation analysis revealed negative association between trappin\u20102 and IL\u20101\u03b2 levels. Trappin\u20102 also showed strong negative correlation with clinical periodontal parameters, in contrast to IL\u20101\u03b2, which showed positive correlation. Trappin\u20102 levels were significantly lower in individuals with CP and GAgP, but not gingivitis, compared with healthy individuals. Reduced salivary concentrations of trappin\u20102 had high sensitivity and specificity to distinguish health from periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Trappin\u20102 is abundant in the saliva of individuals with healthy periodontium in line with its role as an \u201canti\u2010alarm\u201d protease. Decreased salivary trappin\u20102 and increased IL\u20101\u03b2 levels in individuals with periodontitis, compared with healthy individuals, may implicate a potential antiprotease\/proinflammatory cytokine imbalance, resulting in impaired host protective capacity.<\/jats:p><\/jats:sec>","DOI":"10.1902\/jop.2017.170245","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T09:43:27Z","timestamp":1501839807000},"page":"58-66","source":"Crossref","is-referenced-by-count":16,"title":["Alarm anti\u2010protease trappin\u20102 negatively correlates with proinflammatory cytokines in patients with periodontitis"],"prefix":"10.1002","volume":"89","author":[{"given":"Beral","family":"Afacan","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dentistry Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veli \u00d6zgen","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclnur","family":"Emingil","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Ege University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timur","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics School of Medicine Ege University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagihan","family":"Bostanci","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.05.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1111"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0391427"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0095RT"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2008.07.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080746"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.2.582"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/314799"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-1-116"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/bchm3.1995.376.1.1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803707200"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-253"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47198-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2009.136"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01425.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1014.2011.00631.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.11.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/CBI20090290"},{"key":"e_1_2_8_20_1","first-page":"147","volume":"39","author":"Bostanci N","year":"2007","journal-title":"Porphyromonas gingivalis antagonises Campylobacter rectus induced cytokine production by human monocytes. 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