{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:29:08Z","timestamp":1792024148191,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Scientific evidence for psychologic stress as a risk factor for periodontitis is fragmentary and relies mostly on either questionnaire\u2010based or biomarker studies. The aim of this study is to investigate brain\u2010derived neurotrophic factor, substance P, vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), calcitonin gene\u2010related peptide, and adrenomedullin as well as cortisol in saliva and serum in periodontal health and disease combined with different aspects of stress and possible associations with clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 56 patients with aggressive and chronic periodontitis and 44 healthy controls were screened by enzyme\u2010linked immunosorbent assay and mass spectrometry for presence of neuropeptides and cortisol in saliva and serum. Psychologic stress was evaluated by validated questionnaires. All substances were explored for a possible relationship to periodontitis, clinical parameters, and stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VIP and NPY showed significantly higher levels in saliva but not in serum of patients with periodontitis. These neuropeptides correlated with the extent, severity, and bleeding on probing scores in patients with periodontitis. Females had significantly lower salivary VIP levels. There were no differences among participants regarding psychologic stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VIP and NPY in saliva could be potential sex\u2010specific salivary biomarkers for periodontitis regardless of psychologic stress.<\/jats:p><\/jats:sec>","DOI":"10.1902\/jop.2017.170249","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T10:24:22Z","timestamp":1505471062000},"page":"9-18","source":"Crossref","is-referenced-by-count":37,"title":["Salivary neuropeptides, stress, and periodontitis"],"prefix":"10.1002","volume":"89","author":[{"given":"Hady","family":"Haririan","sequence":"first","affiliation":[{"name":"Division of Conservative Dentistry and Periodontology School of Dentistry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleh","family":"Andrukhov","sequence":"additional","affiliation":[{"name":"Competence Center for Periodontal Research Division of Conservative Dentistry and Periodontology Medical University of Vienna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6ttcher","sequence":"additional","affiliation":[{"name":"Medizinisches Versorgungs Zentrum Labor Dessau  Dessau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonore","family":"Pablik","sequence":"additional","affiliation":[{"name":"Section for Medical Statistics Center for Medical Statistics, Informatics, and Intelligent Systems Medical University of Vienna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Wimmer","sequence":"additional","affiliation":[{"name":"Division of Prosthodontics Restorative Dentistry Periodontology, and Implantology School of Dentistry Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Moritz","sequence":"additional","affiliation":[{"name":"Division of Conservative Dentistry and Periodontology School of Dentistry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Rausch\u2010Fan","sequence":"additional","affiliation":[{"name":"Division of Conservative Dentistry and Periodontology School of Dentistry Medical University of Vienna  Vienna Austria"},{"name":"Competence Center for Periodontal Research Division of Conservative Dentistry and Periodontology Medical University of Vienna"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb01485.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1996.tb00508.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2012.00457.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12650"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.288"},{"key":"e_1_2_8_7_1","first-page":"525","volume":"5","author":"Selye H","year":"1956","journal-title":"What is stress? 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