{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:52:55Z","timestamp":1788209575395,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study is to evaluate clinical outcomes of a concept for non\u2010surgical peri\u2010implantitis combining stepwise mechanical debridement measures with adjuvant povidone\u2010iodine application with and without systemic antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five patients with chronic periodontitis and a total of 164 screw\u2010typed implants with peri\u2010implantitis were included. Peri\u2010implantitis was defined as radiographic bone loss of\u00a0&gt;\u00a02\u00a0mm, probing depth (PD)\u00a0\u22655\u00a0mm with bleeding on probing (BOP). Stepwise treatment of implants was performed with ultrasonic debridement, soft tissue curettage (STC), glycine powder air polishing (GPAP), and a repeated submucosal application of povidone\u2010iodine. Teeth with PD\u00a0&gt;\u00a04\u00a0mm were treated simultaneously according to the same concept except STC. In cases with severe periodontitis (n\u00a0=\u00a024), amoxicillin and metronidazole (AM) were prescribed for 7 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 12 months, implants treated without AM showed significant reductions (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) of mean PD (1.4 \u00b1 0.7\u00a0mm), clinical attachment level (CAL) (1.3 \u00b1 0.8\u00a0mm), and BOP (33.4% \u00b1 17.2%). In deep pockets (PD\u00a0&gt;\u00a06\u00a0mm) changes of mean PD (2.3 \u00b1 1.3\u00a0mm), CAL (2.0 \u00b1 1.6\u00a0mm), and BOP (44.0% \u00b1 41.7%) were more pronounced. Intake of AM did not significantly influence the changes in these parameters. However, the reduction of implant sites with PD\u00a0&gt;\u00a04\u00a0mm and BOP was significantly higher in patients with AM than in those without AM (31.8% \u00b1 12.6% versus 20.8% \u00b1 14.7%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of ultrasonic debridement, STC, and GPAP with adjuvant povidone\u2010iodine led to significant clinical improvements at implants. Systemic antibiotics had limited effects on the reduction of persisting implant sites with treatment need.<\/jats:p><\/jats:sec>","DOI":"10.1902\/jop.2017.170362","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T10:24:22Z","timestamp":1505471062000},"page":"139-147","source":"Crossref","is-referenced-by-count":28,"title":["Combination of ultrasonic decontamination, soft tissue curettage, and submucosal air polishing with povidone\u2010iodine application for non\u2010surgical therapy of peri\u2010implantitis: 12\u2010month clinical outcomes"],"prefix":"10.1002","volume":"89","author":[{"given":"Jamal M.","family":"Stein","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry Periodontology and Preventive Dentistry University Hospital Aachen (RWTH)  Aachen Germany"},{"name":"Private practice  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hamm\u00e4cher","sequence":"additional","affiliation":[{"name":"Private practice  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sareh Said\u2010Yekta","family":"Michael","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry Periodontology and Preventive Dentistry University Hospital Aachen (RWTH)  Aachen Germany"},{"name":"Interdisciplinary Center for Clinical Research University Hospital Aachen (RWTH)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516667484"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2016.46.3.136"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12636"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.4150"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01277.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130563"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01276.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02542.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12292"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-015-0023-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01762.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1406-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01051.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01646.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12155"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12689"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12006"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2004.06.005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00919.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12612"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01672.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2009.01232.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2011.640276"},{"key":"e_1_2_8_25_1","first-page":"281","article-title":"Povidone\u2010iodine gel and solution as adjunct to ultrasonic debridement in nonsurgical periodontitis treatment: An RCT pilot study","volume":"45","author":"Sahrmann P","year":"2014","journal-title":"Quintessence Int"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246024"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6_part2.610"},{"key":"e_1_2_8_29_1","first-page":"263","article-title":"Adjuvant antibiotics in the treatment of periodontitis. 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