{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T05:06:16Z","timestamp":1666674376673},"reference-count":0,"publisher":"Ordem dos Medicos","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>A s\u00edndrome hemol\u00edtica ur\u00e9mica at\u00edpica constitui uma microangiopatia tromb\u00f3tica resultante da hiperativa\u00e7\u00e3o da via alterna do complemento.\u00a0A sua gravidade exige diagn\u00f3stico e terap\u00eautica precoces. O diagn\u00f3stico diferencial inclui a s\u00edndrome hemol\u00edtica ur\u00e9mica t\u00edpica\u00a0(associada \u00e0 toxina Shiga) e a p\u00farpura tromb\u00f3tica trombocitop\u00e9nica (associada a defici\u00eancia na atividade da ADAMTS13). A terap\u00eautica\u00a0espec\u00edfica da s\u00edndrome hemol\u00edtica ur\u00e9mica at\u00edpica, atualmente dispon\u00edvel, \u00e9 o eculizumab. Descrevemos um caso cl\u00ednico de uma\u00a0crian\u00e7a com s\u00edndrome hemol\u00edtica ur\u00e9mica at\u00edpica diagnosticada em contexto de diarreia sanguinolenta, complicada de envolvimento\u00a0neurol\u00f3gico e que colocou v\u00e1rios desafios no diagn\u00f3stico e decis\u00f5es terap\u00eauticas.<\/jats:p>","DOI":"10.20344\/amp.10021","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T22:17:57Z","timestamp":1569968277000},"page":"673-675","source":"Crossref","is-referenced-by-count":1,"title":["Desafios Diagn\u00f3sticos e Terap\u00eauticos na S\u00edndrome Hemol\u00edtica Ur\u00e9mica At\u00edpica: A Prop\u00f3sito de Um Caso Cl\u00ednico"],"prefix":"10.20344","volume":"32","author":[{"given":"Sofia","family":"Reis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Cordinh\u00e3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2019,10,1]]},"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/10021\/5775","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/10021\/5775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T20:54:56Z","timestamp":1666644896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/10021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,1]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.10021","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"value":"1646-0758","type":"electronic"},{"value":"0870-399X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10,1]]}}}