{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:33:59Z","timestamp":1787625239332,"version":"build-2736575974"},"reference-count":0,"publisher":"Ordem dos Medicos","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>Introduction: Amongst the inflammatory cells implicated in the immune surveillance of colorectal cancer, a growing body of evidence\u00a0suggests a role for eosinophils in carcinogenesis. We aimed to review the value of tumour-associated tissue eosinophilia (TATE) in the\u00a0prognosis of colorectal cancer emphasizing the identification and measurement of tissue-infiltrating eosinophils and their association\u00a0with the clinicopathological features of the disease.Material and Methods: We used PubMed and Web of Science search engines to retrieve studies that looked at the association\u00a0between tissue eosinophils and colorectal cancer prognosis.Results: We selected 15 studies for our review. In the majority of the studies, eosinophils were identified in hematoxylin-eosin stained\u00a0sections and scores were generated for analysis. Most of the studies pointed to tumour-associated tissue eosinophilia as a favourable\u00a0prognostic marker in colorectal cancer and found an inverse association between eosinophil count and the metastatic potential of\u00a0these neoplasms. The association between tumour-associated tissue eosinophilia and established prognostic markers of colorectal\u00a0cancer was assessed in some studies, with inconsistent results. Additionally, tumour-associated tissue eosinophilia decreased with the\u00a0adenoma-carcinoma progression of colorectal lesions.Discussion: Several mechanisms have been proposed regarding eosinophil chemoatraction to tumour tissues and eosinophil-cancer\u00a0cell cross-talk, suggesting that eosinophils are actively involved in colorectal cancer progression. Although a scoring system is still\u00a0lacking, tumour-associated tissue eosinophilia meets the criteria of a convenient histopathological prognosticator in colorectal cancer.Conclusion: Collectively, current evidence associates the presence of eosinophils in the colorectal cancer microenvironment with the\u00a0modulation of tumour progression. The clinical impact of this finding deserves future research.<\/jats:p>","DOI":"10.20344\/amp.10112","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T08:36:39Z","timestamp":1530520599000},"page":"329-337","source":"Crossref","is-referenced-by-count":25,"title":["New Insights Into the Role of Tissue Eosinophils in the Progression of Colorectal Cancer: A Literature Review"],"prefix":"10.20344","volume":"31","author":[{"given":"Ana Laura","family":"Saraiva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8464","published-online":{"date-parts":[[2018,6,29]]},"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/10112\/5440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/10112\/5440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T08:35:53Z","timestamp":1666686953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/10112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,29]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,29]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.10112","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"value":"1646-0758","type":"electronic"},{"value":"0870-399X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6,29]]}}}