{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:12:10Z","timestamp":1759709530272},"reference-count":0,"publisher":"Ordem dos Medicos","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>Langerhans cell histiocytosis remains an enigmatic disease with a very heterogeneous presentation. We describe a rare case of orbital\u00a0Langerhans cell histiocytosis in a 39-year-old female patient who presented right orbital pain and edema of the upper right eyelid.\u00a0Surgery showed a friable lesion and underlying bone irregularity. Morphological aspects and immunohistochemical profile favored the\u00a0diagnosis of Langerhans cell histiocytosis, which was confirmed with evidence of Langerin expression. The staging tests did not reveal\u00a0any organ involvement, so we decided to follow the algorithm proposed by Euro Histio Net: in case of unifocal disease and in a single\u00a0organ, clinical surveillance was preferred. This case aims to raise awareness of a manifestation of Langerhans cell histiocytosis, which\u00a0should always be considered as a differential diagnosis in adults with osteolytic orbital lesions.<\/jats:p>","DOI":"10.20344\/amp.10179","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T20:46:56Z","timestamp":1567457216000},"page":"617-620","source":"Crossref","is-referenced-by-count":4,"title":["A Case of Orbital Langerhans Cell Histiocytosis in an Adult"],"prefix":"10.20344","volume":"32","author":[{"given":"In\u00eas","family":"Carneiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio","family":"Friande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2019,9,2]]},"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/10179\/5760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/10179\/5760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T21:32:40Z","timestamp":1666647160000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/10179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,2]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,2]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.10179","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"value":"1646-0758","type":"electronic"},{"value":"0870-399X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9,2]]}}}