{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T13:13:36Z","timestamp":1792242816080,"version":"4.4.0"},"reference-count":0,"publisher":"Ordem dos Medicos","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>Introduction: High-risk human papillomavirus cervical infection is currently a well-established cause of cervical cancer. However,\u00a0only a few women with persistent infections will develop cervical precancerous and malignant lesions. Approximately 20% of all cervical cancers are attributable to non-16\/18 serotypes. This study aims to evaluate the results of our clinical approach to women with\u00a0this infection.Material and Methods: We conducted an observational and prospective study from September 2012 to September 2017, which included women with isolated non-16\/18 high-risk human papillomavirus infection (with normal cytology). After re-evaluation, two groups\u00a0were compared: women with spontaneous regression of the infection and women with persistent infection. Clinical and demographic\u00a0data were analysed as well as the rate of progression to precancerous and malignant lesions.Results: We included 165 women, of which 121 were re-evaluated with co-test at least one year later. After re-evaluation, 13.2% of\u00a0women revealed precancerous lesions but only two (1.7%) of them presented high-grade squamous intraepithelial lesions. Sixty-seven\u00a0women (55.4%) showed spontaneous regression of the infection and 54 women (44.6%) maintained it. Women with persistent infection\u00a0developed more precancerous lesions (27.8%; p &lt; 0.001) and high-grade squamous intraepithelial lesions (3.7%; p &lt; 0.001). There\u00a0was also an association between persistent infection and postmenopausal status.Discussion: Human papillomavirus 16\/18 cervical infection is associated with higher risk of cervical cancer when compared with other serotypes.Conclusion: Re-evaluation with co-test one year after the diagnosis of isolated non-16\/18 human papillomavirus infection seems to\u00a0be a reasonable approach.<\/jats:p>","DOI":"10.20344\/amp.10183","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T20:46:56Z","timestamp":1567457216000},"page":"588-592","source":"Crossref","is-referenced-by-count":7,"title":["Isolated Non-16\/18 High-Risk Human Papillomavirus Cervical Infection: Re-Evaluation After One Year"],"prefix":"10.20344","volume":"32","author":[{"given":"Sara","family":"Vargas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pulido","family":"Valente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida Mendes de","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Calhaz-Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8464","published-online":{"date-parts":[[2019,9,2]]},"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/10183\/5755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/10183\/5755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T21:32:38Z","timestamp":1666647158000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/10183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,2]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9,2]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.10183","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"value":"1646-0758","type":"electronic"},{"value":"0870-399X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9,2]]}}}