{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:51:47Z","timestamp":1768722707195,"version":"3.49.0"},"reference-count":0,"publisher":"Ordem dos Medicos","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>A utiliza\u00e7\u00e3o da amantadina na pr\u00e1tica cl\u00ednica ainda parece pouco difundida, apesar da evid\u00eancia crescente na emerg\u00eancia de altera\u00e7\u00f5es do estado de consci\u00eancia ap\u00f3s traumatismo cranioencef\u00e1lico. Descrevemos o caso de um adolescente com traumatismo cranioencef\u00e1lico grave por atropelamento. Ap\u00f3s quatro meses de internamento num hospital central onde se manteve em estado vegetativo foi transferido para um centro de reabilita\u00e7\u00e3o. Iniciou um programa de reabilita\u00e7\u00e3o integral liderado por equipa m\u00e9dica, incluindo estimula\u00e7\u00e3o multissensorial e interven\u00e7\u00e3o no meio envolvente. Iniciou amantadina, 50 mg\/dia, titulada at\u00e9 200 mg\/dia, verificando-se\u00a0melhoria cl\u00ednica e funcional significativas, com emerg\u00eancia para estado de consci\u00eancia m\u00ednima \u00e0 terceira semana e recupera\u00e7\u00e3o da consci\u00eancia \u00e0 sexta semana de amantadina. Manteve melhoria progressiva mesmo ap\u00f3s suspens\u00e3o do f\u00e1rmaco. O caso descrito salienta a import\u00e2ncia da interven\u00e7\u00e3o hol\u00edstica e corrobora a literatura ao demonstrar a efic\u00e1cia e seguran\u00e7a da amantadina na emerg\u00eancia do estado vegetativo.<\/jats:p>","DOI":"10.20344\/amp.11257","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T08:40:16Z","timestamp":1657269616000},"page":"604-609","source":"Crossref","is-referenced-by-count":2,"title":["Do Estado Vegetativo \u00e0 Participa\u00e7\u00e3o: A Amantadina Como Potenciadora do Programa de Reabilita\u00e7\u00e3o"],"prefix":"10.20344","volume":"33","author":[{"given":"Ana","family":"Z\u00e3o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Filipe","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Be\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2020,9,1]]},"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/11257\/6081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/11257\/6081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T22:35:40Z","timestamp":1666564540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/11257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,1]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.11257","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"value":"1646-0758","type":"electronic"},{"value":"0870-399X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9,1]]}}}