{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:48:14Z","timestamp":1762876094929},"reference-count":0,"publisher":"Ordem dos Medicos","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>Until recently, the main goal of chronic myeloid leukemia therapy was disease control with the best overall survival, which required lifelong\u00a0treatment. However, currently, the treatment-free remission concept is becoming an important goal in clinical practice, and several\u00a0tyrosine kinase inhibitors discontinuation studies have shown that\u00a0 round 50% of patients with a durable deep molecular response\u00a0beyond major molecular response successfully interrupt tyrosine kinase inhibitors for at least three years without loss of molecular response.\u00a0However, and regardless of the existing evidence, the exact conditions for attempting treatment-free remission remain poorly\u00a0defined. Different authors tried to guide the clinical decision regarding this topic but there are some points that differ, namely with respect\u00a0to the recommended duration of tyrosine kinase inhibitors therapy and the appropriate molecular response prior to treatment-free\u00a0remission. The goal of this article is to propose an algorithm to guide clinical practice in Portugal concerning chronic phase-chronic\u00a0myeloid leukemia patients who wish to attempt treatment-free remission, since there are no national guidelines.<\/jats:p>","DOI":"10.20344\/amp.11823","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T14:53:11Z","timestamp":1568213591000},"page":"550-557","source":"Crossref","is-referenced-by-count":2,"title":["Recommendations from a Portuguese Expert Group for Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia Patients in Clinical Practice"],"prefix":"10.20344","volume":"32","author":[{"given":"Antonio","family":"Almeida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Pierdomenico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca Polo","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipa","family":"Saraiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Montalv\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio","family":"Mariz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jo\u00e3o","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno","family":"Cerveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2019,8,1]]},"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/11823\/5743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/11823\/5743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T21:33:03Z","timestamp":1666647183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/11823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,1]]},"references-count":0,"journal-issue":{"issue":"7-8","published-online":{"date-parts":[[2019,8,1]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.11823","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"value":"1646-0758","type":"electronic"},{"value":"0870-399X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8,1]]}}}