{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:56:18Z","timestamp":1785826578215,"version":"3.56.0"},"reference-count":0,"publisher":"Ordem dos Medicos","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>Introduction: Graves disease is characterized by the existence of autoantibodies directed to the thyrotropin receptor, which can have\u00a0a stimulatory\/inhibitory action, in women with the condition, their fetus or neonate. Our aim was to review the case series of these\u00a0neonates in order to establish neonatal thyroid function predictors.Material and Methods: Retrospective cohort study of the database of the Department of Pediatric Endocrinology, including patients\u00a0born to mothers with Graves\u2019 disease, between 2002 and 2017. Clinical and biochemical data were collected from mothers and\u00a0offspring.Results: Fifty newborns, from 46 women with a median of 3.5 years after diagnosis, were included. During all trimesters of pregnancy,\u00a0more than half of women had positive autoantibodies directed to the thyrotropin receptor. Not every woman had a complete thyroid\u00a0function evaluation every trimester. In 32 newborns, cord blood screening was done. During the neonatal period, there were three cases\u00a0of hypothyroidism and two of hyperthyroidism. The mothers of these five newborns had higher levels of free thyroid hormones during\u00a0the second trimester (p = 0.03). The level of antibodies directed to the thyrotropin receptor was significantly higher in the cord blood\u00a0(p = 0.03) and in the first neonatal test (p = 0.03) of these dysthyroid newborns.Discussion: Our results reinforce the need for every pregnant woman with Graves\u2019 disease to be subject to thyroid function and\u00a0autoantibodies evaluation during every trimester, as well as the importance of evaluating these antibodies in cord blood.Conclusion: High levels of free thyroid hormones during the second trimester of pregnancy and antibodies directed to the thyrotropin\u00a0receptor value in cord blood are predictors of dysthyroidism in neonates born from women with Grave\u2019s disease.<\/jats:p>","DOI":"10.20344\/amp.12279","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T10:08:13Z","timestamp":1593598093000},"page":"483-490","source":"Crossref","is-referenced-by-count":11,"title":["Neonates Born to Mothers with Graves\u2019 Disease: 15 Year Experience of a Pediatric Endocrinology Department"],"prefix":"10.20344","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2550-5585","authenticated-orcid":false,"given":"In\u00eas Rom\u00e3o","family":"Luz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Rio","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Jer\u00f3nimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana Serra","family":"Caetano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Dinis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Mirante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8464","published-online":{"date-parts":[[2020,7,1]]},"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/12279\/6005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/12279\/6005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T22:50:17Z","timestamp":1666565417000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/12279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,1]]},"references-count":0,"journal-issue":{"issue":"7-8","published-online":{"date-parts":[[2020,7,1]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.12279","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"value":"1646-0758","type":"electronic"},{"value":"0870-399X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7,1]]}}}