{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:04:58Z","timestamp":1787162698289,"version":"build-2736575974"},"reference-count":34,"publisher":"Ordem dos Medicos","issue":"8","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>Introduction: Kaposi\u2019s sarcoma (KS) is a rare angioproliferative neoplasm associated with human herpesvirus 8 infection, presenting as four subtypes: classic, endemic, iatrogenic, and epidemic. While well documented globally, comprehensive data on KS in Portugal remain scarce. The aim of this retrospective study was to provide a detailed analysis of KS cases diagnosed at Hospital Santa Maria, in Lisbon, between 2014 and 2023.Methods: A total of 113 histopathologically confirmed KS cases were included, focusing on demographic, clinical, and histopathological characteristics, as well as treatment strategies and outcomes.Results: The mean age at diagnosis was 59.4 years, with a male-to-female ratio of 4.4:1. Most patients (50.4%) were of African origin. Epidemic KS (45.1%) was the most prevalent subtype. Lesions mainly affected the lower limbs (47.8%), and disseminated, mucosal, and extracutaneous involvement were more common in HIV-positive patients. Tumor-stage lesions were frequent (59.3%). Single-modality treatment was used in 53.1% of cases, while 40.7% required combined therapies. Relapse rates were highest in endemic (39.1%) and iatrogenic KS (28.6%) subtypes. The disease-specific mortality rate was 8%.Conclusion: Our findings suggest that KS remains a significant concern, particularly in immunosuppressed patients. Early diagnosis and multidisciplinary management are essential to improve outcomes. However, limitations such as potential biases from its retrospective design and the single-center scope should be considered.<\/jats:p>","DOI":"10.20344\/amp.17991","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T08:44:28Z","timestamp":1750409068000},"page":"460-468","source":"Crossref","is-referenced-by-count":2,"title":["Kaposi\u2019s Sarcoma: Demographic and Clinical Features, Histopathology, Treatment, and Outcomes in a 10-Year Lisbon Hospital Study"],"prefix":"10.20344","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-6544","authenticated-orcid":false,"given":"In\u00eas","family":"Pereira Amaral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0348-037X","authenticated-orcid":false,"given":"Iv\u00e2nia","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7271-799X","authenticated-orcid":false,"given":"Madalena","family":"Pupo Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4497-9763","authenticated-orcid":false,"given":"In\u00eas","family":"Tribolet Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9950-1521","authenticated-orcid":false,"given":"Filipe","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-7193","authenticated-orcid":false,"given":"Joana","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2085-5463","authenticated-orcid":false,"given":"Nuno","family":"Manso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-1228","authenticated-orcid":false,"given":"Pedro","family":"De Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-6105","authenticated-orcid":false,"given":"Lu\u00eds","family":"Soares de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6917-527X","authenticated-orcid":false,"given":"Paulo","family":"Filipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8464","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"9866","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0152-3"},{"key":"9867","doi-asserted-by":"publisher","DOI":"10.1007\/BF01830024"},{"key":"9868","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"key":"9869","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13225692"},{"key":"9870","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2019.05.008"},{"key":"9871","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.01.008"},{"key":"9872","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00263-3"},{"key":"9873","doi-asserted-by":"publisher","DOI":"10.29021\/spdv.73.2.366"},{"key":"9874","unstructured":"Junger J. Estudo dos doentes com sarcoma de kaposi ap\u00f3s a introdu\u00e7\u00e3o da terap\u00eautica HAART nos \u00faltimos 19 anos no Hospital de Santa Maria \u2013 Lisboa (1994-2012). Lisboa: Universidade de Lisboa; 2013."},{"key":"9875","doi-asserted-by":"publisher","DOI":"10.29021\/spdv.72.4.316"},{"key":"9876","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2021.02.007"},{"key":"9877","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"9878","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00349-2"},{"key":"9879","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2020.101877"},{"key":"9880","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16040691"},{"key":"9881","doi-asserted-by":"publisher","DOI":"10.1159\/000492112"},{"key":"9882","unstructured":"Su \u00d6, Onsun N, Arda H, B\u00fcy\u00fckbabani N, T\u00fcrel-Ermertcan A, \u00d6zt\u00fcrkcan S. Clinical features, presence of human herpesvirus-8 and treatment results in classic kaposi sarcoma. 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