{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T04:15:21Z","timestamp":1744949721470,"version":"3.40.4"},"reference-count":14,"publisher":"Ordem dos Medicos","issue":"6","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>A esferocitose heredit\u00e1ria (EH), embora rara, constitui a principal causa de anemia hemol\u00edtica heredit\u00e1ria, tendo uma apresenta\u00e7\u00e3o cl\u00ednica muito diversa. Raros casos de gr\u00e1vidas com EH est\u00e3o publicados, tendo um impacto incerto nos desfechos maternos e fetais. Os relatos de gesta\u00e7\u00f5es complicadas por EH e de complica\u00e7\u00f5es tromb\u00f3ticas ou hipertens\u00e3o portal s\u00e3o particularmente escassos. Apresentamos o caso de uma gr\u00e1vida esplenectomizada, com EH e hipertens\u00e3o portal n\u00e3o cirr\u00f3tica. A utente apresentava polimorfismos da metiltetrahidrofolato redutase e fator inibidor do ativador do plasminog\u00e9nio, muta\u00e7\u00f5es com impacto controverso no risco tromb\u00f3tico. Durante a gesta\u00e7\u00e3o n\u00e3o ocorreu deteriora\u00e7\u00e3o hemodin\u00e2mica ou hep\u00e1tica, diagnosticando-se restri\u00e7\u00e3o de crescimento fetal tardia que n\u00e3o condicionou t\u00e9rmino precoce da gravidez. Cinco semanas ap\u00f3s o parto, surgiu um quadro de dor abdominal, tendo-se diagnosticado trombose de veia mesent\u00e9rica. Descrevemos a nossa experi\u00eancia de vigil\u00e2ncia da gravidez, parto e puerp\u00e9rio de uma mulher com EH grave, com destaque para potenciais complica\u00e7\u00f5es associadas \u00e0 EH.<\/jats:p>","DOI":"10.20344\/amp.18871","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T13:33:16Z","timestamp":1675863196000},"page":"424-427","source":"Crossref","is-referenced-by-count":0,"title":["Esferocitose Heredit\u00e1ria e Gravidez: A Prop\u00f3sito de um Caso Cl\u00ednico"],"prefix":"10.20344","volume":"36","author":[{"given":"Andreia","family":"Miguel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jos\u00e9","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Catarina","family":"Massa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"2231","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.142463"},{"key":"2232","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08921.x"},{"key":"2233","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20018"},{"key":"2234","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.07.016"},{"key":"2235","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.08.007"},{"key":"2236","doi-asserted-by":"publisher","DOI":"10.1007\/BF02770632"},{"key":"2237","unstructured":"Maberry MC, Mason RA, Cunningham FG, Pritchard JA. 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