{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:17:53Z","timestamp":1768868273112,"version":"3.49.0"},"reference-count":11,"publisher":"Ordem dos Medicos","issue":"12","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>A leishmaniose \u00e9 uma doen\u00e7a parasit\u00e1ria transmitida atrav\u00e9s da picada de flebotom\u00edneos f\u00eamea e que ocorre em regi\u00f5es de clima tropical e subtropical. A leishmaniose visceral \u00e9 a forma mais grave da doen\u00e7a, com uma mortalidade de 95% aos dois anos de infe\u00e7\u00e3o, quando n\u00e3o tratada. A leishmaniose visceral associa-se frequentemente a estados de imunossupress\u00e3o, sendo a coinfe\u00e7\u00e3o com o v\u00edrus da imunodefici\u00eancia humana o mais prevalente. A maioria dos casos de leishmaniose visceral \u00e9 causada pelas esp\u00e9cies Leishmania donovani e Leishmania infantum, sendo esta \u00faltima a esp\u00e9cie end\u00e9mica na bacia do Mediterr\u00e2neo. Em Portugal, o n\u00famero de casos reportados de leishmaniose visceral tem vindo a diminuir nos \u00faltimos anos, sendo que entre 2017 e 2021 foram reportados 15 casos. Os autores apresentam um caso de leishmaniose visceral numa doente imunocompetente, que manifestou a p\u00eantade cl\u00e1ssica: febre, perda ponderal, hepatoesplenomegalia, pancitopenia e hipergamaglobulinemia. O diagn\u00f3stico foi feito pela observa\u00e7\u00e3o de amastigotas da esp\u00e9cie Leishmania infantum no exame anatomopatol\u00f3gico da medula \u00f3ssea e a doente foi tratada com sucesso com anfotericina B liposs\u00f3mica.<\/jats:p>","DOI":"10.20344\/amp.19010","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T12:59:50Z","timestamp":1687525190000},"page":"835-840","source":"Crossref","is-referenced-by-count":3,"title":["Leishmaniose Visceral em Doente Imunocompetente: Relato de um Caso"],"prefix":"10.20344","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3935-7416","authenticated-orcid":false,"given":"Miguel","family":"Rodrigues Monteiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0577-7404","authenticated-orcid":false,"given":"Jo\u00e3o Tiago","family":"Serra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4984-4314","authenticated-orcid":false,"given":"Filipa","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim","family":"Tinoco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"3608","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31204-2"},{"key":"3609","unstructured":"World Health Organization. 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