{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T04:15:07Z","timestamp":1744949707260,"version":"3.40.4"},"reference-count":11,"publisher":"Ordem dos Medicos","issue":"4","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>A linfocitose policlonal persistente de c\u00e9lulas B \u00e9 uma doen\u00e7a rara, caracterizada por linfocitose cr\u00f3nica policlonal, que ocorre mais frequentemente em mulheres fumadoras de meia-idade, que se apresentam assintom\u00e1ticas ou com sintomas inespec\u00edficos. A presen\u00e7a de linf\u00f3citos B binucleados \u00e9 considerada a assinatura citomorfol\u00f3gica desta entidade. A imunofenotipagem comprova a sua origem policlonal, observando-se muitas vezes uma eleva\u00e7\u00e3o da IgM s\u00e9rica. \u00c9 controverso se existe um risco aumentado de desenvolvimento de linfoma. A predisposi\u00e7\u00e3o gen\u00e9tica \u00e9 tamb\u00e9m um fator de risco, al\u00e9m do tabagismo. Apesar da sua natureza policlonal, altera\u00e7\u00f5es gen\u00e9ticas recorrentes est\u00e3o descritas. Na linfocitose policlonal persistente de c\u00e9lulas B a abordagem terap\u00eautica consiste habitualmente numa vigil\u00e2ncia regular, o que refor\u00e7a a import\u00e2ncia do seu reconhecimento. Os autores descrevem o caso de uma mulher de 46 anos, fumadora, com linfocitose cr\u00f3nica, IgM elevada e linf\u00f3citos binucleados. O diagn\u00f3stico diferencial com linfoma assumiu particular import\u00e2ncia, considerando os sintomas constitucionais e esplenomegalia que apresentava.<\/jats:p>","DOI":"10.20344\/amp.19991","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T17:53:26Z","timestamp":1710266006000},"page":"286-288","source":"Crossref","is-referenced-by-count":0,"title":["Linfocitose Policlonal Persistente de C\u00e9lulas B (LPPB): Uma Entidade que N\u00e3o \u00c9 o que Parece"],"prefix":"10.20344","volume":"37","author":[{"given":"Ant\u00f3nio","family":"Figueiredo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diogo","family":"Paulino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Severino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1riam","family":"Cal\u00fa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Barreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"5435","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198207223070407"},{"key":"5436","unstructured":"Online Mendelian Inheritance in Man, OMIM\u00ae. 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