{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:03:29Z","timestamp":1747202609939,"version":"3.40.5"},"reference-count":9,"publisher":"Ordem dos Medicos","issue":"3","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>A doen\u00e7a de Hansen, vulgarmente conhecida como lepra, \u00e9 uma doen\u00e7a infecciosa causada por Mycobacterium leprae. Sendo rara nos pa\u00edses desenvolvidos, configura uma doen\u00e7a de importa\u00e7\u00e3o cada vez mais frequente considerando o fluxo migrat\u00f3rio de pa\u00edses onde \u00e9 end\u00e9mica. Apresentamos o caso de um homem de 21 anos que recorreu ao servi\u00e7o de urg\u00eancia por poliartralgias de car\u00e1ter aditivo envolvendo grandes articula\u00e7\u00f5es, p\u00e1pulas e placas eritematosas nos membros com bolhas e necrose central e febre com calafrio com uma semana de evolu\u00e7\u00e3o. Foi realizada bi\u00f3psia cut\u00e2nea que revelou infiltrado neutrof\u00edlico com granulomas de distribui\u00e7\u00e3o perineural e baciloscopia com dete\u00e7\u00e3o de bacilos \u00e1cido-\u00e1lcool resistentes. Foi estabelecido o diagn\u00f3stico de DH multibacilar com rea\u00e7\u00e3o lepromatosa tipo 2 (eritema nodoso leproso), apresentando melhoria cl\u00ednica sob corticoterapia. O eritema nodoso leproso cursa habitualmente com les\u00f5es dolorosas, configurando uma apresenta\u00e7\u00e3o at\u00edpica de lepra, sobretudo na presen\u00e7a de bolhas e necrose, tornando este diagn\u00f3stico altamente desafiante. O estigma social \u00e9 frequentemente limitativo na aceita\u00e7\u00e3o da doen\u00e7a e ades\u00e3o ao tratamento.<\/jats:p>","DOI":"10.20344\/amp.20599","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T21:30:09Z","timestamp":1706218209000},"page":"215-219","source":"Crossref","is-referenced-by-count":0,"title":["Doen\u00e7a de Hansen: Apresenta\u00e7\u00e3o Incomum de uma Doen\u00e7a Antiga"],"prefix":"10.20344","volume":"37","author":[{"given":"M\u00e1rio","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7530-8750","authenticated-orcid":false,"given":"Carlos","family":"Grij\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1575-4983","authenticated-orcid":false,"given":"Joana","family":"Paulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7498-0836","authenticated-orcid":false,"given":"Marta","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7727-039X","authenticated-orcid":false,"given":"Z\u00e9lia","family":"Neves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Bouceiro Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"4904","unstructured":"Organiza\u00e7\u00e3o Mundial da Sa\u00fade. Global leprosy update, 2018: moving towards a leprosy-free world. Weekly Epidemiological Record. 2019;94:389-412."},{"key":"4905","doi-asserted-by":"publisher","DOI":"10.29021\/spdv.77.4.1116"},{"key":"4906","unstructured":"Scollard D, Stryjewska B, Dacso M. Leprosy: epidemiology, microbiology, clinical manifestations and diagnosis. Up-to-date. 2019. [consultado 2023 dez 01]. Dispon\u00edvel em: www.uptodate.com\/contents\/leprosy-epidemiology-microbiology-clinical-manifestations-and-diagnosis."},{"key":"4907","unstructured":"Ramos-e-Silva M, Ribeiro de Castro MC. Mycobacterial infections. In: Bolognia JL, Schaffer JV, Cerroni L, editors. Dermatology. 4\u00aa ed. Amsterdam: Elsevier; 2018. p.1296-303."},{"key":"4908","unstructured":"Gelbert RH. Leprosy. In: Jameson JL, Kasper DL, Longo DL, Fauci AS, Hauser SL, Loscalzo J, editors. Harrison\u2019s principles of internal medicine. 20\u00aa ed. New York: McGraw Hill Education; 2018. p.1259-66."},{"key":"4909","unstructured":"Bloom BR, Grosset JH, Lechat MF, Due LK, Nkinda SJ, Rao CK, et al. WHO Expert Committee on Leprosy. World Heal Organ Tech Rep Ser. 2012;768:7-50"},{"key":"4910","unstructured":"Organiza\u00e7\u00e3o Mundial da Sa\u00fade. Guidelines for the diagnosis, treatment and prevention of leprosy. Geneve: WHO; 2017."},{"key":"4911","unstructured":"Ridley DS, Jopling WH. Classification of leprosy according to immunity. A five-group system. Int J Lepr. 1966;34:255-73."},{"key":"4912","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.034"}],"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/20599\/15352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/20599\/15352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T14:17:49Z","timestamp":1744899469000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/20599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3,1]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.20599","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"type":"electronic","value":"1646-0758"},{"type":"print","value":"0870-399X"}],"subject":[],"published":{"date-parts":[[2024,1,25]]}}}