{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:03:38Z","timestamp":1747202618776,"version":"3.40.5"},"reference-count":25,"publisher":"Ordem dos Medicos","issue":"12","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>O presente protocolo cl\u00ednico foi desenhado para servir como um guia hospitalar na abordagem diagn\u00f3stica, terap\u00eautica e de monitoriza\u00e7\u00e3o da neuross\u00edfilis, tendo em conta a positividade ou n\u00e3o para o v\u00edrus de imunodefici\u00eancia humana. A s\u00edfilis \u00e9 uma doen\u00e7a sexualmente transmiss\u00edvel, de notifica\u00e7\u00e3o obrigat\u00f3ria, conhecida como a grande imitadora nosol\u00f3gica. Em cerca de 30% dos casos de doen\u00e7a n\u00e3o tratada ocorre infe\u00e7\u00e3o persistente do sistema nervoso central. A neuross\u00edfilis \u00e9 uma forma grave e progressiva de s\u00edfilis, que pode ocorrer em qualquer est\u00e1dio da doen\u00e7a, com frequente atraso no diagn\u00f3stico e tratamento. Classifica-se como neuross\u00edfilis precoce (meningite sifil\u00edtica, neuross\u00edfilis meningovascular ou gomas sifil\u00edticas) e neuross\u00edfilis tardia (gomas sifil\u00edticas, dem\u00eancia sifil\u00edtica ou tabes dorsalis). A import\u00e2ncia da pun\u00e7\u00e3o lombar prende-se n\u00e3o s\u00f3 com quest\u00f5es diagn\u00f3sticas, mas tamb\u00e9m com a avalia\u00e7\u00e3o da efic\u00e1cia do tratamento. O tratamento desta patologia em todos os est\u00e1dios consiste em penicilina por via parent\u00e9rica. Com este protocolo pretende-se facilitar a decis\u00e3o cl\u00ednica nos casos de suspeita de neuross\u00edfilis atrav\u00e9s de uma conduta sistematizada, individualizada e multidisciplinar.<\/jats:p>","DOI":"10.20344\/amp.21847","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T18:21:45Z","timestamp":1733163705000},"page":"871-882","source":"Crossref","is-referenced-by-count":0,"title":["Abordagem Diagn\u00f3stica, Terap\u00eautica e de Monitoriza\u00e7\u00e3o na Suspeita de Neuross\u00edfilis: Proposta de Protocolo Cl\u00ednico"],"prefix":"10.20344","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-3453","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Martins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Canelas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2411-1499","authenticated-orcid":false,"given":"Beatriz","family":"Prista-Le\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-1362","authenticated-orcid":false,"given":"Cl\u00e1udio","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5331-9934","authenticated-orcid":false,"given":"Andreia","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2077-3356","authenticated-orcid":false,"given":"Andr\u00e9","family":"Silva-Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"7586","doi-asserted-by":"crossref","unstructured":"Chow F. 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