{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:53:32Z","timestamp":1769010812454,"version":"3.49.0"},"reference-count":46,"publisher":"Ordem dos Medicos","issue":"1","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>Os v\u00edrus Marburgo e \u00c9bola pertencem \u00e0 fam\u00edlia Filoviridae e s\u00e3o conhecidos por causar doen\u00e7as zoon\u00f3ticas emergentes. Estes v\u00edrus apresentam alta letalidade e s\u00e3o facilmente transmiss\u00edveis de pessoa para pessoa, o que os torna potencialmente capazes de desencadear epidemias, inclusive em regi\u00f5es n\u00e3o end\u00e9micas, sendo tamb\u00e9m considerados agentes de bioterrorismo. Os morcegos frug\u00edvoros s\u00e3o os reservat\u00f3rios naturais destes filov\u00edrus. A transmiss\u00e3o para humanos ocorre atrav\u00e9s do contacto direto com fluidos corporais ou tecidos de humanos ou animais infetados. A forma mais grave da doen\u00e7a causada por filov\u00edrus manifesta-se como hemorragia mucocut\u00e2nea, frequentemente acompanhada por fal\u00eancia multiorg\u00e2nica, que \u00e9 a principal causa de morte. Tradicionalmente, estas doen\u00e7as s\u00e3o classificadas no grupo das febres hemorr\u00e1gicas virais, embora este termo esteja a ser abandonado, pois nem sempre h\u00e1 manifesta\u00e7\u00f5es hemorr\u00e1gicas ou febre na hist\u00f3ria cl\u00ednica dos doentes. Atualmente, n\u00e3o existe um tratamento antiviral espec\u00edfico para a doen\u00e7a causada por filov\u00edrus, e a abordagem terap\u00eautica consiste em medidas de suporte. Existem, no entanto, tr\u00eas vacinas licenciadas para o v\u00edrus \u00c9bola do Zaire assim como anticorpos monoclonais indicados no tratamento e na profilaxia p\u00f3s-exposi\u00e7\u00e3o. Devido \u00e0 import\u00e2ncia em termos de sa\u00fade p\u00fablica e \u00e0 possibilidade da ocorr\u00eancia de casos fora de \u00c1frica, esta revis\u00e3o tem como objetivo aprimorar o conhecimento cl\u00ednico e a abordagem de casos suspeitos de doen\u00e7a causada por filov\u00edrus. A melhoria na vigil\u00e2ncia e a prepara\u00e7\u00e3o para potenciais surtos globais s\u00e3o medidas essenciais paraobter uma resposta eficaz a estas amea\u00e7as de sa\u00fade p\u00fablica e para garantir que os profissionais de sa\u00fade est\u00e3o bem informados e preparados para lidar com estas doen\u00e7as.<\/jats:p>","DOI":"10.20344\/amp.21911","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T21:04:34Z","timestamp":1732136674000},"page":"42-48","source":"Crossref","is-referenced-by-count":2,"title":["Doen\u00e7a Causada por Filov\u00edrus: Uma Atualiza\u00e7\u00e3o"],"prefix":"10.20344","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7590-8425","authenticated-orcid":false,"given":"Rafael","family":"Marx de Andrade","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2948-768X","authenticated-orcid":false,"given":"Andreia","family":"Paulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5213-1473","authenticated-orcid":false,"given":"Em\u00edlia","family":"Valadas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0556-5310","authenticated-orcid":false,"given":"Vitor","family":"Laerte Pinto Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"7451","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.200900005"},{"key":"7452","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2023.09.025"},{"key":"7453","doi-asserted-by":"publisher","DOI":"10.1007\/82_2017_8"},{"key":"7454","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1239079"},{"key":"7455","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0147-3"},{"key":"7456","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2005.06.007"},{"key":"7457","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1387628"},{"key":"7458","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00376-6"},{"key":"7459","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0187-4"},{"key":"7460","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aivir.2017.12.002"},{"key":"7461","unstructured":"Howley PM, Knipe DM. 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