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Due to uncontrolled hypertension and persistent pain, and after evaluating the maternal and fetal risk-benefit, a cesarean section was performed at 29 weeks and six days. During the postoperative period, a multi-drug regimen was required for blood pressure control, but the patient recovered and was discharged. Genetic testing, prompted by a family history of sudden death (brother) and aortic dissection (father), identified a mutation in the FBN1 gene, confirming Marfan syndrome. This case highlights the importance of comprehensive patient history, the challenges of aortic dissection during pregnancy, and the need for a multidisciplinary approach in these cases. <\/jats:p>","DOI":"10.20344\/amp.22287","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T12:38:13Z","timestamp":1742992693000},"page":"491-495","source":"Crossref","is-referenced-by-count":0,"title":["Acute Aortic Dissection in the Third Trimester of Pregnancy as an Initial Presentation of Marfan Syndrome"],"prefix":"10.20344","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5923-3540","authenticated-orcid":false,"given":"Marta","family":"Reis Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Valentim Louren\u00e7o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1173-6171","authenticated-orcid":false,"given":"Maria","family":"Pulido Valente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"doi-asserted-by":"publisher","key":"8269","DOI":"10.3390\/jpm12071148"},{"doi-asserted-by":"publisher","key":"8270","DOI":"10.1002\/clc.22165"},{"doi-asserted-by":"publisher","key":"8271","DOI":"10.1111\/jocs.15575"},{"doi-asserted-by":"publisher","key":"8272","DOI":"10.1053\/j.semvascsurg.2022.02.010"},{"doi-asserted-by":"publisher","key":"8273","DOI":"10.1111\/jocs.15068"},{"doi-asserted-by":"publisher","key":"8274","DOI":"10.1093\/eurheartj\/ehae179"},{"doi-asserted-by":"publisher","key":"8275","DOI":"10.1001\/jamacardio.2020.4884"},{"doi-asserted-by":"publisher","key":"8276","DOI":"10.1093\/eurheartj\/ehy478"},{"doi-asserted-by":"publisher","key":"8277","DOI":"10.1111\/chd.12465"},{"doi-asserted-by":"publisher","key":"8278","DOI":"10.15420\/usc.2022.36"},{"doi-asserted-by":"publisher","key":"8279","DOI":"10.1161\/CIRCULATIONAHA.110.988568"},{"doi-asserted-by":"publisher","key":"8280","DOI":"10.1016\/j.athoracsur.2024.01.021"},{"doi-asserted-by":"publisher","key":"8281","DOI":"10.1097\/AOG.0000000000002355"},{"doi-asserted-by":"publisher","key":"8282","DOI":"10.1016\/j.ijcard.2005.11.116"},{"doi-asserted-by":"publisher","key":"8283","DOI":"10.1055\/a-2072-0469"},{"doi-asserted-by":"publisher","key":"8284","DOI":"10.1016\/j.repc.2018.05.013"},{"doi-asserted-by":"publisher","key":"8285","DOI":"10.1016\/j.ajog.2011.09.002"}],"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/22287\/15626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/22287\/15626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T08:45:24Z","timestamp":1754124324000},"score":1,"resource":{"primary":{"URL":"https:\/\/actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/22287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":17,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8,1]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.22287","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"type":"electronic","value":"1646-0758"},{"type":"print","value":"0870-399X"}],"subject":[],"published":{"date-parts":[[2025,3,26]]}}}