{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:23:52Z","timestamp":1764782632466,"version":"3.46.0"},"reference-count":62,"publisher":"Ordem dos Medicos","issue":"12","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>O manuscrito re\u00fane indica\u00e7\u00f5es de vacina\u00e7\u00e3o para adultos imunocomprometidos com base nas recomenda\u00e7\u00f5es das principais institui\u00e7\u00f5es de refer\u00eancia internacional. Estes indiv\u00edduos apresentam maior vulnerabilidade a doen\u00e7as infeciosas preven\u00edveis por vacinas e a prote\u00e7\u00e3o vacinal \u00e9 frequentemente inferior \u00e0 dos imunocompetentes. Por isso, \u00e9 importante avaliar a resposta \u00e0 vacina (serol\u00f3gica ou outra) sempre que poss\u00edvel. Salienta-se a import\u00e2ncia de adaptar a vacina\u00e7\u00e3o ao net state of immunosuppression precedida por avalia\u00e7\u00e3o cuidadosa do risco, indica\u00e7\u00f5es, contraindica\u00e7\u00f5es e momento ideal de administra\u00e7\u00e3o. Sempre que poss\u00edvel, a vacina\u00e7\u00e3o deve ser efetuada antes do in\u00edcio da imunossupress\u00e3o farmacol\u00f3gica, antes de esplenectomia ou antes de receber um transplante de \u00f3rg\u00e3o s\u00f3lido. Os imunocomprometidos s\u00e3o categorizados em grupos como: portadores de doen\u00e7as inflamat\u00f3rias imunomoduladas, esplenectomizados, recetores de transplantes de \u00f3rg\u00e3os s\u00f3lidos ou hematopoi\u00e9ticos, indiv\u00edduos com infe\u00e7\u00e3o por HIV e aqueles com imunodefici\u00eancias cong\u00e9nitas (erros inatos) e s\u00e3o detalhadas as indica\u00e7\u00f5es de vacina\u00e7\u00e3o em diferentes situa\u00e7\u00f5es cl\u00ednicas e tipos de imunossupress\u00e3o. Abordam-se as vacinas para doen\u00e7as virais respirat\u00f3rias como gripe, COVID-19, v\u00edrus sincicial respirat\u00f3rio, as vacinas da hepatite A e B, varicela-zoster e a prote\u00e7\u00e3o vacinal contra bact\u00e9rias encapsuladas como pneumococos, meningococos e Haemophilus influenzae. Incluem-se ainda algumas recomenda\u00e7\u00f5es de vacina\u00e7\u00e3o em contexto de viagem e profilaxia p\u00f3s-exposi\u00e7\u00e3o para situa\u00e7\u00f5es de elevado risco. Aborda-se a vacina\u00e7\u00e3o dos conviventes e dos profissionais de sa\u00fade para prote\u00e7\u00e3o adicional. Destaca-se que a evolu\u00e7\u00e3o das vacinas e das recomenda\u00e7\u00f5es vacinais obriga a uma atualiza\u00e7\u00e3o constante.<\/jats:p>","DOI":"10.20344\/amp.22966","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T16:58:21Z","timestamp":1764694701000},"page":"814-827","source":"Crossref","is-referenced-by-count":0,"title":["Recomenda\u00e7\u00f5es de Vacina\u00e7\u00e3o no Doente Adulto Imunocomprometido"],"prefix":"10.20344","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6464-7063","authenticated-orcid":false,"given":"C\u00e2ndida","family":"Abreu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8568-4234","authenticated-orcid":false,"given":"Susana","family":"Peres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3202-1688","authenticated-orcid":false,"given":"Fl\u00e1via","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-4315","authenticated-orcid":false,"given":"Joana","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-1362","authenticated-orcid":false,"given":"Cl\u00e1udio","family":"Nunes-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2077-3356","authenticated-orcid":false,"given":"Andr\u00e9","family":"Silva-Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8548-6393","authenticated-orcid":false,"given":"L\u00facia","family":"Ribeiro-Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2687-7260","authenticated-orcid":false,"given":"Joaquim","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"11461","unstructured":"Infectious Diseases Society of America, Centers for Disease Control and Prevention. 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