{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:22:58Z","timestamp":1791559378498,"version":"4.3.4"},"reference-count":13,"publisher":"Ordem dos Medicos","issue":"8","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>The use of subcutaneous and intramuscular progesterone injections for non-therapeutic purposes has become increasingly common in Africa, particularly in Angola, where weak regulation allows unsupervised use. We report the case of a 26-year-old Angolan woman who developed lipomembranous panniculitis after six months of daily subcutaneous progesterone injections for libido enhancement at a non-medical center. She presented with erythematous-brown nodules and plaques, and a skin biopsy confirmed granulomatous inflammation and adipocyte death. Treatment with prednisolone and naproxen resolved the inflammation, but hyperpigmentation persisted. This case highlights the serious risks of off-label progesterone injections, particularly in unregulated aesthetic procedures, and underscores the need for stricter regulations and public health interventions.<\/jats:p>","DOI":"10.20344\/amp.23042","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T16:56:24Z","timestamp":1765472184000},"page":"477-480","source":"Crossref","is-referenced-by-count":2,"title":["Lipomembranous Panniculitis Induced by Repeated Progesterone Injections for Libido Enhancement: A Case Report"],"prefix":"10.20344","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-6544","authenticated-orcid":false,"given":"In\u00eas","family":"Pereira Amaral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0348-037X","authenticated-orcid":false,"given":"Iv\u00e2nia","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2511-8619","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Pereira Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-6105","authenticated-orcid":false,"given":"Lu\u00eds","family":"Soares de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6917-527X","authenticated-orcid":false,"given":"Paulo","family":"Filipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8464","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"11263","unstructured":"Quiala S. Jardas: os efeitos nefastos da busca pelo corpo perfeito. 2023. [cited 2025 Sep 11]. Available from: https:\/\/www.dw.com\/pt-002\/jardas-em-angola-os-efeitos-nefastos-da-busca-pelo-corpo-perfeito\/video-65379096."},{"key":"11264","doi-asserted-by":"publisher","DOI":"10.15761\/COGRM.1000296"},{"key":"11265","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(03)00136-7"},{"key":"11266","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2014.05.003"},{"key":"11267","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu194"},{"key":"11268","unstructured":"Patterson JW. Weedon\u2019s skin pathology. 5th ed. 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