{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:03:46Z","timestamp":1790870626416,"version":"4.1.0"},"reference-count":15,"publisher":"Ordem dos Medicos","issue":"10","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>Methylphenidate (MPH) is a widely prescribed psychostimulant for the management of attention deficit hyperactivity disorder (ADHD). Although most adverse effects of MPH are transient and reversible, hepatotoxicity remains a rare but potentially serious complication. We present the case of a 12-year-old female patient with ADHD who had been receiving MPH treatment since the age of 8. After three and a half years of therapy, she did blood tests that showed a marked elevation in transaminases and gamma-glutamyl transferase. Extensive evaluation ruled out alternative causes of liver disease, and liver biopsy findings were consistent with drug-induced hepatitis. Discontinuation of MPH resulted in progressive normalization of liver enzyme levels. This case underscores the importance of regular laboratory monitoring during long-term psychostimulant therapy, particularly regarding liver function. Early recognition of abnormal biochemical findings allows for prompt discontinuation of the offending drug, reversal of hepatic injury, and prevention of more severe complications such as liver failure.<\/jats:p>","DOI":"10.20344\/amp.23703","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T15:41:03Z","timestamp":1765986063000},"page":"641-643","source":"Crossref","is-referenced-by-count":1,"title":["Drug-Induced Hepatitis Caused by Methylphenidate: A Case Report"],"prefix":"10.20344","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-3024","authenticated-orcid":false,"given":"Diana","family":"Valbom Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5988-9604","authenticated-orcid":false,"given":"Mariana","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4849-7493","authenticated-orcid":false,"given":"S\u00f3nia","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4078-4153","authenticated-orcid":false,"given":"Sandra","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8286-4026","authenticated-orcid":false,"given":"Sandra","family":"Rebimbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8464","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"11289","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/437298"},{"key":"11290","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-2528"},{"key":"11291","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009885.pub3"},{"key":"11292","unstructured":"Methylphenidate. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda: National Institute of Diabetes and Digestive and Kidney Diseases; 2012."},{"key":"11293","unstructured":"Francis P, Navarro V. Drug-induced hepatotoxicity. In: StatPearls. Treasure Island: StatPearls Publishing; 2025."},{"key":"11294","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.02.014"},{"key":"11295","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2023.2451"},{"key":"11296","unstructured":"Attention Deficit\/Hyperactivity Disorder (ADHD) Agents. In: LiverTox: Clinical and research information on drug-induced liver injury. Bethesda: National Institute of Diabetes and Digestive and Kidney Diseases; 2012."},{"key":"11297","unstructured":"Bernhard MK, Hugle B, Merkenschlager A. Elevated liver enzymes under therapy with methylphenidate in a boy with T-cell leukemia. J Pediatr Neurol. 2009;7:297-9."},{"key":"11298","unstructured":"Torres EL, Valle V, Pachkoria K, Cueto Gal\u00e1n R, Lucena Gonz\u00e1lez MI, et al. Hepatotoxicidad por metilfenidato en el tratamiento del trastorno por d\u00e9ficit de atenci\u00f3n con hiperactividad. Actualidad En Farmacolog\u00eda y Terap\u00e9utica. 2005;3:270-271."},{"key":"11299","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198404000-00010"},{"key":"11300","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(85)80790-3"},{"key":"11301","unstructured":"Goodman CR. Hepatotoxicity due to methylphenidate hydrochloride. N Y State J Med. 1972;72:2339-40."},{"key":"11302","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9525-2"},{"key":"11303","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.58"}],"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/23703\/15829","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/23703\/15829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:41:07Z","timestamp":1790869267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/23703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":15,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.23703","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"value":"1646-0758","type":"electronic"},{"value":"0870-399X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,17]]}}}