{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T11:03:49Z","timestamp":1780311829167,"version":"3.54.0"},"reference-count":15,"publisher":"Ordem dos Medicos","issue":"6-7","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>A mordedura de v\u00edbora-cornuda (Vipera latastei), esp\u00e9cie end\u00e9mica da Pen\u00ednsula Ib\u00e9rica, provoca habitualmente toxicidade local e hematol\u00f3gica, podendo originar coagulopatia de consumo. Apresenta-se o caso de um homem de 39 anos mordido no quarto dedo da m\u00e3o esquerda. A primeira dose de soro antiof\u00eddico (ViperFav\u00ae) foi administrada 10 horas ap\u00f3s o incidente, com necessidade de duas doses adicionais por persist\u00eancia de coagulopatia e trombocitopenia transit\u00f3ria. Implementaram-se medidas adjuvantes, cuja utiliza\u00e7\u00e3o e benef\u00edcios se encontram em discuss\u00e3o na comunidade m\u00e9dica: oxigenoterapia hiperb\u00e1rica (10 sess\u00f5es) e penso transd\u00e9rmico de nitroglicerina para otimizar a perfus\u00e3o local. A evolu\u00e7\u00e3o foi favor\u00e1vel, com preserva\u00e7\u00e3o da viabilidade digital e resolu\u00e7\u00e3o laboratorial progressiva. Este caso evidencia a import\u00e2ncia da administra\u00e7\u00e3o precoce do ant\u00eddoto, da vigil\u00e2ncia hematol\u00f3gica cont\u00ednua e o potencial benef\u00edcio de integrar terap\u00eauticas adjuvantes na preven\u00e7\u00e3o de necrose e complica\u00e7\u00f5es sist\u00e9micas. A abordagem multidisciplinar permitiu a recupera\u00e7\u00e3o funcional completa sem sequelas.<\/jats:p>","DOI":"10.20344\/amp.24300","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:18:37Z","timestamp":1780309117000},"page":"405-408","source":"Crossref","is-referenced-by-count":0,"title":["Mordedura de V\u00edbora Cornuda: Caso Cl\u00ednico e Revis\u00e3o de Abordagem Terap\u00eautica"],"prefix":"10.20344","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8238-0293","authenticated-orcid":false,"given":"Cristiano","family":"Gante","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6166-3145","authenticated-orcid":false,"given":"Adriana","family":"Watts Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Brazete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Terceiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"Rato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8464","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"13040","doi-asserted-by":"crossref","unstructured":"Valdoleiros SR, Gon\u00e7alves I, Silva C, Guerreiro D, Silva L, Martinez-Freiria F, et al. Animais venenosos em territ\u00f3rio portugu\u00eas. Acta Med Port. 2021;34:784-95.","DOI":"10.20344\/amp.15589"},{"key":"13041","unstructured":"Centro de Informa\u00e7\u00e3o Antivenenos. Dados estat\u00edsticos de 2024. Lisboa: INEM; 2024."},{"key":"13042","doi-asserted-by":"crossref","unstructured":"Seifert SA, Armitage J, Sanchez E. Snake envenomation. N Engl J Med. 2022;386:68-78.","DOI":"10.1056\/NEJMra2105228"},{"key":"13043","doi-asserted-by":"crossref","unstructured":"Maduwage K, Isbister GK. Current treatment for venom-induced consumption coagulopathy resulting from snakebite. PLoS Negl Trop Dis. 2014;8:e3220.","DOI":"10.1371\/journal.pntd.0003220"},{"key":"13044","unstructured":"World Health Organization. Guidelines for the management of snakebites. 2nd ed. New Delhi: WHO; 2016."},{"key":"13045","doi-asserted-by":"crossref","unstructured":"Warrell DA. Venomous bites, stings, and poisoning: an update. Infect Dis Clin North Am. 2019;33:17-38.","DOI":"10.1016\/j.idc.2018.10.001"},{"key":"13046","doi-asserted-by":"crossref","unstructured":"Boyer LV, Seifert SA, Clark R, McNally J, Williams S, Nordt S, et al. Recurrent and persistent coagulopathy following pit viper envenomation. Arch Intern Med. 1999;159:706-10.","DOI":"10.1001\/archinte.159.7.706"},{"key":"13047","doi-asserted-by":"crossref","unstructured":"Ca\u00f1as CA. Is the acute compartment syndrome diagnosed in snake bites true?: A review. Medicine. 2024;103:e40008.","DOI":"10.1097\/MD.0000000000040008"},{"key":"13048","doi-asserted-by":"crossref","unstructured":"Stewart RM, Page CP, Schwesinger WH, McCarter R, Martinez J, Aust J. Antivenin and fasciotomy\/debridement in the treatment of the severe rattlesnake bite. Am J Surg. 1989;158:543-7.","DOI":"10.1016\/0002-9610(89)90188-8"},{"key":"13049","unstructured":"Garfin SR, Castilonia RR, Mubarak S, HArgens W, Akeson W, Russel F. Role of surgical decompression in treatment of rattlesnake bites. Surg Forum. 1979;30:502."},{"key":"13050","doi-asserted-by":"crossref","unstructured":"Hall EL. Role of surgical intervention in the management of crotaline snake envenomation. Ann Emerg Med. 2001;37:175-80.","DOI":"10.1067\/mem.2001.113373"},{"key":"13051","doi-asserted-by":"crossref","unstructured":"Korambavil N, Ambookan P, Abrahan S, Ambalakat A. A multidisciplinary approach with hyperbaric oxygen therapy improves outcome in snake bite injuries. Toxicol Int. 2015;22:104.","DOI":"10.4103\/0971-6580.172287"},{"key":"13052","unstructured":"Hochedez P, Mehdaouni L. Hyperbaric oxygen therapy after Bothrops lanceolatus snake bites in Martinique: a brief report. Undersea Hyperb Med. 2010;37:399-403."},{"key":"13053","doi-asserted-by":"crossref","unstructured":"Ince B, Gundeslioglu N. Management of viper bites on the hand. J Hand Surg Eur Vol. 2014;39:642-6.","DOI":"10.1177\/1753193413496943"},{"key":"13054","doi-asserted-by":"crossref","unstructured":"DeVito R, Stranix J. Is nitropaste effective in stressed flaps? Ann Plast Surg. 2023;90:S356-8.","DOI":"10.1097\/SAP.0000000000003339"}],"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/24300\/15975","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/24300\/15975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:18:44Z","timestamp":1780309124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/24300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":15,"journal-issue":{"issue":"6-7","published-online":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.24300","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"value":"1646-0758","type":"electronic"},{"value":"0870-399X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,1]]}}}