{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:33:51Z","timestamp":1789104831719,"version":"build-2803163510"},"reference-count":0,"publisher":"Ordem dos Medicos","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>A doen\u00e7a intersticial pulmonar ocorre em at\u00e9 cerca de 25% dos doentes com s\u00edndrome de Sj\u00f6gren e em 2% - 8% dos doentes com\u00a0l\u00fapus eritematoso sist\u00e9mico. Os corticoster\u00f3ides permanecem como pilar de tratamento do l\u00fapus eritematoso sist\u00e9mico mas podem\u00a0associar-se a complica\u00e7\u00f5es neuropsiqui\u00e1tricas, sobretudo com doses de prednisolona superiores a 40 mg\/dia. Apresentamos o caso\u00a0de uma doente de 51 anos com s\u00edndrome depressiva, l\u00fapus eritematoso sist\u00e9mico e s\u00edndrome de Sj\u00f6gren secund\u00e1ria que desenvolveu\u00a0envolvimento pulmonar grave evidente quatro anos ap\u00f3s o diagn\u00f3stico, com tomografia computadorizada de t\u00f3rax a revelar padr\u00e3o de\u00a0neofibrose e vidro despolido. Com o aumento da prednisolona para 60 mg\/dia a doente iniciou um quadro man\u00edaco com necessidade\u00a0de internamento e que foi admitido no contexto de corticoterapia em dose elevada. Foi exclu\u00eddo envolvimento neurol\u00f3gico central\u00a0por doen\u00e7a org\u00e2nica. Iniciou ciclofosfamida endovenosa mensal durante seis meses seguida de micofenolato de mofetil, tendo-se\u00a0reduzido prednisolona at\u00e9 10 mg\/dia e mantido hidroxicloroquina 400 mg\/dia, com controlo da atividade da doen\u00e7a.<\/jats:p>","DOI":"10.20344\/amp.7297","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T16:25:51Z","timestamp":1492446351000},"page":"246-250","source":"Crossref","is-referenced-by-count":2,"title":["Doen\u00e7a Intersticial Pulmonar Grave e Mania Induzida por Corticoster\u00f3ides em Doente com L\u00fapus Eritematoso Sist\u00e9mico e S\u00edndrome de Sj\u00f6gren Secund\u00e1ria"],"prefix":"10.20344","volume":"30","author":[{"given":"Sofia Silv\u00e9rio","family":"Serra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Pedrosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Falc\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime Cunha","family":"Branco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"8464","published-online":{"date-parts":[[2017,3,31]]},"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/7297\/4975","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/7297\/4975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T20:52:06Z","timestamp":1666731126000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/7297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,31]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,31]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.7297","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"value":"1646-0758","type":"electronic"},{"value":"0870-399X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3,31]]}}}