{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T04:23:33Z","timestamp":1666758213809},"reference-count":0,"publisher":"Ordem dos Medicos","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>Introdu\u00e7\u00e3o: A s\u00edndrome clinicamente isolada \u00e9 uma forma de apresenta\u00e7\u00e3o da esclerose m\u00faltipla, doen\u00e7a desmielinizante cr\u00f3nica do\u00a0sistema nervoso central, e define-se por um \u00fanico epis\u00f3dio cl\u00ednico sugestivo de desmieliniza\u00e7\u00e3o. Por\u00e9m, doentes com esta s\u00edndrome\u00a0podem n\u00e3o desenvolver novos sintomas ou les\u00f5es, mesmo ap\u00f3s longos per\u00edodos de seguimento, n\u00e3o cumprindo os crit\u00e9rios de\u00a0diagn\u00f3stico da doen\u00e7a. Aqui ser\u00e3o revistas, na s\u00edndrome clinicamente isolada, as altera\u00e7\u00f5es na resson\u00e2ncia magn\u00e9tica que melhor\u00a0predizem a convers\u00e3o em esclerose m\u00faltipla.Material e M\u00e9todos: Pesquisaram-se na base de dados da PubMed artigos publicados entre janeiro de 2010 e junho de 2015 usando\u00a0os termos \u2018clinically isolated syndrome\u2019, \u2018cis\u2019, \u2018multiple sclerosis\u2019, \u2018magnetic resonance imaging\u2019, \u2018magnetic resonance\u2019 e \u2018mri\u2019.Resultados: Carga lesional, localiza\u00e7\u00e3o das les\u00f5es, crit\u00e9rios de Barkhof e \u00e1reas\/volumes de estruturas cerebrais foram as altera\u00e7\u00f5es\u00a0na resson\u00e2ncia magn\u00e9tica convencional encontradas nos artigos inclu\u00eddos nesta revis\u00e3o. As t\u00e9cnicas n\u00e3o convencionais estudadas\u00a0foram a dupla invers\u00e3o-recupera\u00e7\u00e3o, a transfer\u00eancia de magnetiza\u00e7\u00e3o, a espectroscopia e a imagem de tensor de difus\u00e3o.Discuss\u00e3o: Enquanto o n\u00famero de les\u00f5es e a sua localiza\u00e7\u00e3o t\u00eam um papel claro na previs\u00e3o da convers\u00e3o da s\u00edndrome clinicamente\u00a0isolada em esclerose m\u00faltipla, as t\u00e9cnicas n\u00e3o convencionais e as restantes altera\u00e7\u00f5es na resson\u00e2ncia magn\u00e9tica necessitam de mais\u00a0estudos para confirmar a sua capacidade de prever o desenvolvimento da doen\u00e7a.Conclus\u00e3o: Para al\u00e9m do valor preditivo das altera\u00e7\u00f5es j\u00e1 citadas, no futuro, diferentes achados neurorradiol\u00f3gicos na s\u00edndrome clinicamenteisolada poder\u00e3o ser considerados para os crit\u00e9rios de diagn\u00f3stico da esclerose m\u00faltipla e\/ou modificar as recomenda\u00e7\u00f5es\u00a0sobre o seu tratamento.<\/jats:p>","DOI":"10.20344\/amp.7650","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T09:36:02Z","timestamp":1480671362000},"page":"742-748","source":"Crossref","is-referenced-by-count":1,"title":["Altera\u00e7\u00f5es na Resson\u00e2ncia Magn\u00e9tica Preditoras da Convers\u00e3o da S\u00edndrome Clinicamente Isolada em Esclerose M\u00faltipla"],"prefix":"10.20344","volume":"29","author":[{"given":"Sara","family":"Peixoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2016,11,30]]},"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/7650\/4824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/7650\/4824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T21:07:52Z","timestamp":1666732072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/7650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,30]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,30]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.7650","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"value":"1646-0758","type":"electronic"},{"value":"0870-399X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11,30]]}}}