{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T04:22:36Z","timestamp":1666758156390},"reference-count":0,"publisher":"Ordem dos Medicos","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>Molar pregnancy, included in gestational trophoblastic disease, is a benign pathology with ability to metastasize, usually occurring with\u00a0excessively high \u03b2hCG levels. Clinical scenario is usually a woman in extremes of reproductive age presenting with amenorrhoea,\u00a0pain and vaginal blood loss; signs derived from high \u03b2hCG levels may be present (hyperthyroidism, hyperemesis). Diagnosis is based\u00a0on a positive pregnancy test \u2013 usually a qualitative urinary test. The limitation of this test results from its inability to become positive\u00a0in presence of markedly high levels of \u03b2hCG, saturating the antigens used \u2013 known as the \u2018hook effect\u2019. With the widespread use\u00a0of gynaecological ultrasound cases of molar pregnancy have been diagnosed in timely fashion. We describe a case referred as\u00a0a degenerating fibroid, with a negative urinary pregnancy test. Transvaginal ultrasound was highly suggestive of molar pregnancy,\u00a0which was confirmed with a quantitative \u03b2hCG test, allowing for timely treatment. The importance of a high index of suspicion for this\u00a0pathology is tremendous to avoid the devastating consequences of a delayed diagnosis.<\/jats:p>","DOI":"10.20344\/amp.8603","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T07:48:34Z","timestamp":1507708114000},"page":"656-658","source":"Crossref","is-referenced-by-count":0,"title":["Negative \u03b2hCG and Molar Pregnancy: The Hook Effect"],"prefix":"10.20344","volume":"30","author":[{"given":"Isabel","family":"Lobo Antunes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana","family":"Curado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Quintas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alcides","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2017,9,29]]},"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/8603\/5155","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/8603\/5155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T20:29:50Z","timestamp":1666729790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/8603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,29]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2017,9,29]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.8603","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"value":"1646-0758","type":"electronic"},{"value":"0870-399X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9,29]]}}}