{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T18:17:49Z","timestamp":1762021069716,"version":"build-2065373602"},"reference-count":0,"publisher":"Ordem dos Medicos","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med Port"],"abstract":"<jats:p>Cerca de 28% dos doentes com dislipidemia apresentam na sua etiologia causas secund\u00e1rias. A resolu\u00e7\u00e3o de algumas destas causas pode levar \u00e0 corre\u00e7\u00e3o total da dislipidemia. Descreve-se o caso de uma doente do sexo feminino, 50 anos, com obesidade grau II e cirrose biliar prim\u00e1ria referenciada por dislipidemia mista com mau controlo (sob estatina e fibrato) e com altera\u00e7\u00f5es anal\u00edticas hep\u00e1ticas. No estudo efetuado constatou-se hipotiroidismo prim\u00e1rio auto-imune. Ap\u00f3s normaliza\u00e7\u00e3o da fun\u00e7\u00e3o tiroideia pelo tratamento com levotiroxina, al\u00e9m da suspens\u00e3o da estatina e fibrato, verificou-se melhoria do perfil lip\u00eddico, embora mantendo hipercolesterolemia. Neste per\u00edodo de tempo foi-lhe diagnosticada diabetes mellitus pelo que se instituiu de novo terap\u00eautica com estatina (atorvastatina 10 mg), com normaliza\u00e7\u00e3o do perfil lip\u00eddico. Com este caso pretende-se salientar a import\u00e2ncia da exclus\u00e3o de causas secund\u00e1rias de dislipidemia, nomeadamente o hipotiroidismo, bem como discutir aspectos particulares do tratamento com estatinas na doen\u00e7a hep\u00e1tica.<\/jats:p>","DOI":"10.20344\/amp.9944","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T13:13:36Z","timestamp":1583154816000},"page":"204-207","source":"Crossref","is-referenced-by-count":3,"title":["Dislipidemia Secund\u00e1ria a Hipotiroidismo e Colestase"],"prefix":"10.20344","volume":"33","author":[{"given":"Ana","family":"Saavedra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabete","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"8464","published-online":{"date-parts":[[2020,3,2]]},"container-title":["Acta M\u00e9dica Portuguesa"],"original-title":[],"link":[{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/9944\/5890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/download\/9944\/5891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T20:46:50Z","timestamp":1666644410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actamedicaportuguesa.com\/revista\/index.php\/amp\/article\/view\/9944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,2]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,2]]}},"URL":"https:\/\/doi.org\/10.20344\/amp.9944","relation":{},"ISSN":["1646-0758","0870-399X"],"issn-type":[{"type":"electronic","value":"1646-0758"},{"type":"print","value":"0870-399X"}],"subject":[],"published":{"date-parts":[[2020,3,2]]}}}