{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T16:57:40Z","timestamp":1678208260560},"reference-count":23,"publisher":"Korea Society for Exercise Nutrition","issue":"4","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1D1A1B07048750","2019S1A5A2A03051702"],"award-info":[{"award-number":["2018R1D1A1B07048750","2019S1A5A2A03051702"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-pan.org"],"crossmark-restriction":true},"short-container-title":["Phys Act Nutr"],"published-print":{"date-parts":[[2021,12,31]]},"abstract":"<jats:p>[Purpose] Deleted in breast cancer 1 (DBC1) ablation causes obesity, and stearoyl-CoA desaturase 1 (SCD1) induces the biosynthesis of monounsaturated fatty acids. This study examined whether voluntary wheel running (VWR) alters SCD-1 and DBC1 protein levels in the liver of leptin-deficient ob\/ob mice.[Methods] Twenty-five Ob\/Ob mice were divided into two groups (ob\/ob-Sed and ob\/ob-Ex). The expression of DBC1 and SCD1 in the mouse liver was determined using western blotting.[Results] After 10 weeks, VWR significantly reduced body weight without affecting the fatty acid synthase and CD36 protein levels. The average daily running distance was 4.0\u00b11.0 km\/day. This improvement was associated with changes in the hepatic SCD1 and DBC1 levels. Hepatic SCD-1 protein levels increased significantly, and DBC1 protein levels decreased in ob\/ob-Sed animals. On the other hand, VWR inhibited the obesity-induced increase in SCD1 expression and impaired the obesity-induced decrease in DBC1 expression in the liver of leptin-deficient ob\/ob mice.[Conclusion] This is the first study showing that VWR has strong effects on hepatic SCD1 and DBC1 in ob\/ob mice, and provides key insights into the effects of exercise on obesity.<\/jats:p>","DOI":"10.20463\/pan.2021.0026","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T07:26:29Z","timestamp":1643009189000},"page":"54-58","update-policy":"http:\/\/dx.doi.org\/10.20463\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Voluntary exercise training improves body weight of leptin-deficient ob\/ob mice by altering hepatic stearoyl-CoA desaturase 1 and deleted in breast cancer 1 protein 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